Document Detail


Infliximab efficacy in nail psoriasis. A retrospective study in 48 patients.
MedLine Citation:
PMID:  20707829     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background  Nail psoriasis occurs in up to half of psoriatic patients and can lead to significant physical impairment and pain. To date, patients and clinicians are actually dissatisfied by current therapeutic approaches. Objective  Our main aim is to evaluate Infliximab efficacy in nail psoriasis. Methods  We performed an open-label and uncontrolled retrospective study considering all psoriatic patients presenting recalcitrant nail involvement and receiving Infliximab in our Department during the period between January 2008 and March 2009. We calculated nail psoriasis severity index (NAPSI) score at 0, 14, 22 and 38 weeks and percentage of patients achieving NAPSI-50,-75,-90 at 14, 22 and 38 weeks. Results  We observed a rapid nail improvement in most cases after 22 weeks of Infliximab therapy, but a complete nail clearing was reached in only five (10.4%) patients. We don't have a follow-up longer than 38 weeks to assess long-term efficacy of this treatment in nail psoriasis. Conclusions  Infliximab, in our experience, has proved to be effective in reducing nail lesions and, in some cases, even clearing them. Our data demonstrate long-term efficacy of this biological agent in nail psoriasis.
Authors:
C Fabroni; A Gori; M Troiano; F Prignano; T Lotti
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Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  25     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  549-53     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
Affiliation:
University Unit of Dermatology and Physiotherapy, University of Florence, Via Lorenzo il Magnifico, Florence, Italy.
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