Document Detail

Infliximab and anterior optic neuropathy: case report and review of the literature.
MedLine Citation:
PMID:  19916016     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anti-tumor necrosis factor alpha (TNF alpha) agents have been increasingly used to treat patients with Crohn's disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and persistent uveitis. We describe a 68-year-old man with Crohn's esophagitis who developed a possible bilateral toxic anterior optic neuropathy during infliximab infusion. METHODS: This is an observational case report, with review of the PubMed literature from 1977 to present. RESULTS: This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated anterior optic neuropathy have been reported in the literature to date. CONCLUSION: It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab.
Jane W Chan; Alberto Castellanos
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-11-15
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv f?r klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Neurology and Ophthalmology, University of Kentucky College of Medicine, KY Clinic L-445, Lexington, KY 40536, USA.
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MeSH Terms
Anti-Inflammatory Agents / adverse effects*
Antibodies, Monoclonal / adverse effects*
Crohn Disease / drug therapy*
Esophagitis / drug therapy*
Optic Neuropathy, Ischemic / chemically induced*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/infliximab

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