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Infliximab treatment of Familial Mediterranean fever and its effect on secondary AA amyloidosis.
MedLine Citation:
PMID:  17043487     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We describe a patient with a long history of familial Mediterranean fever who developed proteinuria as a result of secondary AA amyloidosis. In this patient, the inflammatory process, including recurrent attacks of arthritis, abdominal pain, nephrotic syndrome secondary to amyloidosis, and high sedimentation rate, was rapidly suppressed by treatment with infliximab and there was remarkable improvement of the proteinuria.Because TNF-alpha is a proinflammatory cytokine that plays a major role in FMF and secondary amyloid, it is an appropriate target for therapy. Our case is the first case of reactive systemic amyloidosis secondary to familial Mediterranean fever, which responded favorably to infliximab.
Authors:
Samy Metyas; Daniel G Arkfeld; Deborah M Forrester; Glenn R Ehresmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  10     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2006-10-17     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-7     Citation Subset:  -    
Affiliation:
LAC+USC Medical Center, Los Angeles, California, USA.
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