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Inflammatory response in preterm infants is induced early in life by oxygen and modulated by TPN.
MedLine Citation:
PMID:  20531248     Owner:  NLM     Status:  Publisher    
The intravenous lipid emulsion (LIP) is a source of oxidants which may stimulate inflammation. Co-administration of parenteral multivitamins (MVP) with LIP prevents lipid peroxidation in light exposed TPN. We hypothesised that this modality of TPN administration affects systemic inflammation, which may be modulated by exposure to oxygen. Premature infants were allocated to 3 TPN regimens; AA: MVP co-administered with amino acid/dextrose exposed to ambient light, LIP provided separately (n=9); LE: MVP co-administered with light-exposed LIP (n=9); LP: MVP co-administered with light-protected LIP (n=8). In LE and LP, amino acid/dextrose was provided separately. Upon reaching full TPN, infants were sampled for IL-6 and IL-8 in plasma and the redox potential of glutathione in whole blood (E, mV). Data were compared (ANOVA) in infants exposed to low (<0.25) vs high (>/=0.25) FiO2. Patients (mean +/-SD: birth weight 797+/-172 g; gestational age 26+/-1 wk) had similar clinical characteristics in TPN groups. Cytokine levels correlated positively (p<0.01) with FiO2 and E. High FiO2 stimulated an increase (p<0.01) in cytokines in AA, while these markers remained unaffected by oxygen in the LE and LP groups. The choice of a TPN admixture may have important consequences on the systemic inflammatory response triggered by an oxidant stress. (200/200) ABBREVIATIONS::
Pascal M Lavoie; Jean Claude Lavoie; Carla Watson; Thérèse Rouleau; Brent A Chang; Philippe Chessex
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-6-7
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Neonatology [P.M.L., C.W., B.A.C, P.C.], Children's and Women's Health Centre of BC, University of British Columbia, Vancouver V6H 3V4, BC, Canada; Department of Pediatrics [J.C.L., T.R], Hospital Ste-Justine, University of Montreal, Montreal H3T 1C5, QC, Canada.
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