Document Detail

Inflammatory response in the acute phase of deep vein thrombosis.
MedLine Citation:
PMID:  11932666     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Deep vein thrombosis (DVT) is a multifactorial disease. Recently, inflammation has been suggested as a risk factor for DVT. The question is whether inflammation is a cause of venous thrombosis or rather a result of the thrombotic process.
METHODS: We studied the inflammatory response in the acute phase of DVT with interleukin-6, interleukin-8, and C-reactive protein (CRP) as inflammatory markers. Plasma concentrations were measured on the day of admission (day 0) in 40 patients with acute DVT confirmed with phlebography and in 33 patients with clinical suspicion of DVT but negative phlebography results (controls). In patients with DVT, inflammatory markers were also examined on five subsequent days.
RESULTS: On day 0, the median concentrations in plasma of interleukin-6, interleukin-8, and CRP were 15.0 pg/mL (range, <3 to 70 pg/mL), 7.0 pg/mL (range, <3 to 76 pg/mL), 37.5 mg/L (range, <7 to 164 mg/L), respectively, in the patient group and less than 3 pg/mL (range, <3 to 11 pg/mL; P <.001), 6.0 pg/mL (range, <3 to 52 pg/mL; P =.08), and 5.0 pg/L (range, <7 to 66 pg/L; P <.001), respectively, in the controls. During the next days, interleukin-6 concentration showed a gradual decline in patients with DVT from 15.0 to 5.5 pg/mL (P <.001), interleukin-8 concentration was relatively constant in time, and CRP concentration declined from 37.5 to 21.5 mg/L (P =.01).
CONCLUSION: Our data show an apparent inflammatory response with highest measured concentrations of inflammatory markers on the day of admission and a subsequent decrease during the next days. This response supports the hypothesis that elevated inflammatory markers are a result rather than a cause of venous thrombosis.
Edith M Roumen-Klappe; Martin den Heijer; Stan H M van Uum; Johanna van der Ven-Jongekrijg; Fedde van der Graaf; Hub Wollersheim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  35     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-05-15     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-6     Citation Subset:  IM    
Department of General Internal Medicine, University Medical Center Nijmegen, The Netherlands.
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MeSH Terms
Acute-Phase Reaction / blood,  diagnosis,  etiology*
C-Reactive Protein / metabolism
Case-Control Studies
Fibrin Fibrinogen Degradation Products / metabolism
Interleukin-6 / blood
Interleukin-8 / blood
Middle Aged
Risk Factors
Venous Thrombosis / blood,  diagnosis,  immunology*
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Interleukin-6; 0/Interleukin-8; 0/fibrin fragment D; 9007-41-4/C-Reactive Protein

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