Document Detail

Inflammatory pulmonary edema and positive end-expiratory pressure: correlations between imaging and physiologic studies.
MedLine Citation:
PMID:  3292784     Owner:  NLM     Status:  MEDLINE    
The anatomic and physiologic response to positive end-expiratory pressure (PEEP) was investigated using computed tomography (CT) in patients with adult respiratory distress syndrome (ARDS). The lesions (densities) in ARDS are distributed inhomogeneously but tend to concentrate in the dependent regions. The estimated lung weight (by CT scan, quantitative analysis, and lung gas volume measured with helium dilution) is, on the average, 200% higher than expected. Changing the body position from supine to prone causes a change in the density distribution in response to gravitational forces. The main effect of PEEP is to clear the densities through alveolar anatomic recruitment. Anatomic recruitment changes the mechanical characteristics of the lung and parallels the improvement in gas exchange. The effects of PEEP on pulmonary arterial pressure appear to be related to anatomic recruitment.
L Gattinoni; A Pesenti; S Baglioni; G Vitale; M Rivolta; P Pelosi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of thoracic imaging     Volume:  3     ISSN:  0883-5993     ISO Abbreviation:  J Thorac Imaging     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-23     Completed Date:  1988-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606160     Medline TA:  J Thorac Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Istituto di Anestesiologia e Rianimazione, Milano, Italy.
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MeSH Terms
Lung / pathology,  physiopathology
Lung Compliance
Organ Size
Positive-Pressure Respiration*
Pulmonary Edema / physiopathology*,  radiography
Pulmonary Ventilation
Respiration, Artificial*
Respiratory Distress Syndrome, Adult / physiopathology*,  radiography
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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