Document Detail

Inflammatory pseudotumor of the spleen with EBV positivity: report of a case.
MedLine Citation:
PMID:  15089768     Owner:  NLM     Status:  MEDLINE    
Inflammatory pseudotumor (IPT) of the spleen is a rare benign tumor with unknown etiology. It causes problems in the diagnosis because of mimicking some hematopoetic malignancies. Here we report the case of a 36-yr-old woman complaining of nausea and insomnia. Laboratory investigations were limited to increase of leukocyte and thrombocyte count. Ultrasonography and magnetic resonance (MR) imaging showed circumscribed solid lobulated mass, measuring about 6.5 cm in diameter, located in the dorsal region of the spleen. Splenectomy was performed with the differential diagnosis including hamartoma and lymphoma of the spleen. Histological examination of the sharply demarcated splenic mass consisted of myofibroblasts and admixture of inflammatory cells. Immunohistochemistry and in situ hybridization were performed. IPT of the spleen was diagnosed. Epstein-Barr virus (EBV) was detected in the tumor by in situ hybridization. This rare entity is presented because of its clinical, radiological and pathological difficulties in the differential diagnosis.
F Oz Puyan; S Bilgi; E Unlu; O Yalcin; S Altaner; M Demir; B Cakir
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  72     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  IM    
Department of Pathology, Trakya University Medical Faculty, Edirne, Turkey.
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MeSH Terms
Diagnosis, Differential
Epstein-Barr Virus Infections / virology*
Granuloma, Plasma Cell / diagnosis,  surgery,  virology*
Hamartoma / diagnosis
Herpesvirus 4, Human / isolation & purification*
In Situ Hybridization
Lymphoma / diagnosis
Magnetic Resonance Imaging
Splenic Diseases / diagnosis,  surgery,  virology*

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