Document Detail

Inflammatory profiles in nasal mucosa of patients with persistent vs intermittent allergic rhinitis.
MedLine Citation:
PMID:  20192943     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To date there is little information on the inflammatory profiles of patients suffering from persistent (PER) and intermittent allergic rhinitis (IAR). Also, it is not clear whether differences exist in eosinophilic inflammation and/or T-helper cell sub-populations and their markers. The aim of this study was to primarily evaluate the inflammatory profiles of patients with moderate/severe PER and IAR.
METHODS: Inferior nasal turbinate tissue was obtained from 12 PER, 12 IAR and 12 nonallergic nonrhinitic (control) patients, and symptoms (visual analogue scales, VAS) and impairment of life was monitored. All tissues were assessed for eosinophil and mast cell numbers by immunohistochemistry; IL-5, ECP and IgE concentrations by immunoassay; mRNA for transcription factors GATA-3, T-bet, FOXP3 and RORc by quantitative real-time polymerase chain reaction; and IgE-induced release of LTC(4)/D(4)/E(4) and PGD(2)in vitro.
RESULTS: Eosinophils and mast cells were significantly increased in patients with PER and patients with IAR compared to control subjects; by patients with PER demonstrating even significantly greater increase of both cell types than patients with IAR. Similarly, ECP IL-5, GATA-3 mRNA expression and IgE-induced release of LTC4/D(4)/E(4) and PGD(2) from mast cells were significantly increased in patients with PER compared to patients with IAR. In contrast, the expression of T-bet, FOXP3 or RORc mRNA was not significantly different in the PER, IAR or control patients.
CONCLUSION: The findings from the present study suggest that PER is characterized by a significantly greater eosinophilic and predominantly Th2 cell-mediated nasal inflammatory profile compared to IAR.
F Liu; J Zhang; Y Liu; N Zhang; G Holtappels; P Lin; S Liu; C Bachert
Related Documents :
7833173 - Acute and late adverse reactions to low-osmolal contrast media.
9525443 - Discontinuing venom immunotherapy: extended observations.
19338993 - High prevalence of polycystic ovary syndrome in women with mild hirsutism and no other ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-02-26
Journal Detail:
Title:  Allergy     Volume:  65     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1149-57     Citation Subset:  IM    
Department of Oto-Rhino-Laryngology, West China Medical School, Sichuan University, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Eosinophilia / immunology
Eosinophils / cytology,  immunology
GATA3 Transcription Factor / metabolism
Inflammation / immunology*,  physiopathology
Interleukin-5 / metabolism
Mast Cells / cytology,  immunology
Nasal Mucosa / immunology*,  physiopathology
Rhinitis, Allergic, Perennial / immunology*,  physiopathology
Rhinitis, Allergic, Seasonal / immunology*,  physiopathology
Th2 Cells / metabolism
Young Adult
Reg. No./Substance:
0/GATA3 Transcription Factor; 0/Interleukin-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  IgE in the human placenta: why there?
Next Document:  The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced...