Document Detail


Inflammatory processes and Alzheimer's disease.
MedLine Citation:
PMID:  15853506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inflammatory hypothesis of Alzheimer's disease, which states that anti-inflammatory drugs could have beneficial effects on the pathophysiology of Alzheimer's disease, has been extensively investigated in clinical, epidemiological and basic research studies over the last 20 years. However, despite much hope, the hypothesis remains unproven. Although the results from the first small clinical trial with an anti-inflammatory agent in Alzheimer's disease appeared promising, subsequent trials with a variety of anti-inflammatory agents have failed to show beneficial effects. There are many potential reasons for this including drug selection, drug dose, timing and duration of treatment. This article reviews evidence in support of the inflammatory hypothesis in Alzheimer's disease, as well as the progress of clinical trials using specific anti-inflammatory treatment regimens. It is concluded that such treatments should not be recommended, although additional investigation is warranted.
Authors:
Sally Walsh; Paul S Aisen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  4     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2006-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  793-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA. spw9@georgetown.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / epidemiology,  physiopathology*
Anti-Inflammatory Agents / therapeutic use*
Clinical Trials as Topic / methods
Expert Testimony
Humans
Inflammation / drug therapy*,  etiology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents

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