| Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: a case-control study. | |
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MedLine Citation:
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PMID: 19307820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether levels of interleukin (IL)-6, IL-10, and oxidative parameters in umbilical cord blood could contribute as an indicator of neonatal sepsis in recognized high-risk neonates. DESIGN: Prospective, case-control study. SETTING: Neonatal intensive care unit. SUBJECTS: One hundred twenty consecutive preterm neonates who had at least one other risk factor for early-onset neonatal sepsis. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Umbilical cord blood samples were obtained for the determination of IL-6, IL-10, thiobarbituric acid reactive substances (TBARS), and protein carbonyls levels. Neonates were divided prospectively in two groups: control and septic. All parameters were higher in septic patients compared with control (IL-6 184.6 +/- 72.7 vs. 58.9 +/- 19.1, p < 0.01; IL-10 171.4 +/- 59.2 vs. 79.9 +/- 17.9, p < 0.01; TBARS 10.1 +/- 2.8 vs. 4.2 +/- 2.5, p < 0.01; protein carbonyls 2.4 +/- 1.2 vs. 1.15 +/- 0.5, p < 0.01, respectively, septic vs. control). In addition, these parameters were higher in the subgroup of culture-positive septic patients compared with control. IL-6 and TBARS had equivalent areas under the receiver operator characteristic (ROC) curve (0.88); IL-10 (0.80) and protein carbonyls (0.73) had lower areas. Multivariate logistic regression comparing IL-6 and TBARS in terms of the relative risk for neonatal sepsis demonstrated that TBARS was a better predictor, being independently associated with neonatal sepsis. CONCLUSION: Our findings demonstrated that cord blood IL-6, IL-10, and oxidative stress markers were significantly higher in infants with neonatal sepsis, and only TBARS levels were independently related to the development of neonatal sepsis in our sample. |
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Authors:
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Ana Carolina Cancelier; Fabricia Petronilho; Adalisa Reinke; Larissa Constantino; Roberta Machado; Cristiane Ritter; Felipe Dal-Pizzol |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Volume: 10 ISSN: 1529-7535 ISO Abbreviation: Pediatr Crit Care Med Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-08 Completed Date: 2009-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954653 Medline TA: Pediatr Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 467-71 Citation Subset: IM |
Affiliation:
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Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Case-Control Studies Female Fetal Blood / chemistry* Humans Infant, Newborn Infant, Premature Inflammation / blood Intensive Care Units, Neonatal Interleukin-10 / blood* Interleukin-6 / blood* Male Oxidative Stress* Prospective Studies Protein Carbonylation ROC Curve Risk Factors Sepsis / blood*, diagnosis*, microbiology Streptococcus agalactiae / isolation & purification Thiobarbituric Acid Reactive Substances / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 0/Thiobarbituric Acid Reactive Substances; 130068-27-8/Interleukin-10 |
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