Document Detail


Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report.
MedLine Citation:
PMID:  17168442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory myofibroblastic tumor is an uncommon lesion which mainly develops in the lung and is extremely rare in the larynx. It may be easily misinterpreted as a malignant epithelial or mesenchymal spindle cell neoplasm. Histological and clinical knowledge of this lesion is important to exclude misdiagnosis and inappropriate treatment. We report a case of inflammatory myofibroblastic tumor arising on the right vocal cord of a 23-year-old man. The tumor was composed of a mixture of spindle cells and inflammatory elements. Immunohistochemical investigation revealed that the neoplastic cells expressed anaplastic lymphoma kinase (ALK) protein.
Authors:
Guido Bellezza; Antonio Cavaliere; Rachele Del Sordo; Angelo Sidoni
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tumori     Volume:  92     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-12-15     Completed Date:  2006-12-28     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  449-51     Citation Subset:  IM    
Affiliation:
Institute of Pathologic Anatomy and Histology, Division of Cancer Research, Perugia Medical School, University of Perugia, Perugia, Italy. guidobellezza@virgilio.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Inflammation / enzymology
Laryngeal Neoplasms / enzymology*,  pathology
Male
Neoplasms, Muscle Tissue / enzymology*,  pathology
Protein-Tyrosine Kinases / metabolism*
Up-Regulation
Chemical
Reg. No./Substance:
EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/anaplastic lymphoma kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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