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Inflammatory mediators involved in the progression of metabolic syndrome.
MedLine Citation:
PMID:  22389088     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Metabolic syndrome consists of a constellation of risk factors including primarily abdominal obesity, hyperglycemia, low high-density lipoproteins, hypertriglyceridemia, and hypertension. It encompasses Type 2 diabetes mellitus, dyslipidemia, atherosclerosis, hypertension, hepatic steatosis and so on. Recent studies enhanced our understanding of molecular mechanisms of the inflammatory progression in metabolic syndrome. Especially, a number of inflammatory mediators including cytokines, adipokines and eicosanoids induced inflammatory responses that eventually lead to the development of metabolic syndrome. Therefore, measuring the levels of certain inflammatory molecules might provide useful information on the inflammatory state, which may have clinical importance and significance. The selective intervention of some of these molecules might have the therapeutic potential to modulate inflammatory responses, and thereby could alter disease progression. In this review, we would briefly summarize the recent studies on classical and newer inflammatory mediators in the pathogenesis of different human and experimental metabolic syndrome. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Kuifen Ma; Xi Jin; Xingguang Liang; Qingwei Zhao; Xingguo Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-2
Journal Detail:
Title:  Diabetes/metabolism research and reviews     Volume:  -     ISSN:  1520-7560     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883450     Medline TA:  Diabetes Metab Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003. jancemkf@163.com.
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