| Inflammatory mediators in acute pancreatitis. | |
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MedLine Citation:
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PMID: 7881958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cellular events leading to acute pancreatitis are not well defined and the mechanism by which known aetiological factors initiate the disease process remains to be established. Inflammatory mediators have recently been implicated as potential early markers of disease severity and may help elucidate the pathophysiology of the disease. Oxidative stress is emerging as a common effector of the acinar cell injury in experimental acute pancreatitis and clinical findings indicate that neutrophil activation is a significant early event. In common with neutrophil-mediated tissue damage in states of tissue hypoperfusion, acute pancreatitis shows many features of an ischaemia-reperfusion injury. Increased levels of phospholipase A2 have been demonstrated; this enzyme induces synthesis of prostaglandins and platelet-activating factor, a potent inflammatory mediator. New therapeutic approaches to the complications of acute pancreatitis may be through manipulation of such mediators of inflammation. |
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Authors:
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L J Formela; S W Galloway; A N Kingsnorth |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The British journal of surgery Volume: 82 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-04-11 Completed Date: 1995-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 6-13 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Biological Markers / blood Clinical Trials as Topic Humans Pancreatitis / blood, etiology*, pathology, therapy Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Br J Surg. 1995 Jun;82(6):855
[PMID:
7627535
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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