Document Detail


Inflammatory mechanisms involving neutrophils in chronic venous insufficiency of lower limbs.
MedLine Citation:
PMID:  11725375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It is supposed that an inflammatory reaction is one of the major factors responsible for the chronic venous insufficiency (CVI) of lower limbs which cause leg ulcers. OBJECTIVES: The main objective of the present study was to determine the differences in the levels of typical inflammatory mediators and markers produced by neutrophils of patients with CVI and normal control subjects. SUBJECTS AND METHODS: 26 patients with CVI and 39 clinically healthy subjects were included in the study. In peripheral neutrophils of both groups the production of superoxide, total reactive oxygen intermediates and activities of lysosomal enzymes were measured together with the expression of 8 adhesion molecules. RESULTS: Increased formation of superoxide by patient neutrophils and activities of elastase in both neutrophils and serum of patients were demonstrated. On the contrary, activities of myeloperoxidase and beta-D-glucuronidase were decreased in patient neutrophils. Comparing to control group adhesion molecules CD11b, CD18, CD31, CD49d, CD54 and CD62L were increased on the surface of patient neutrophils whereas no differences were observed in the expression of CD11a abd CD15. CONCLUSION: The neutrophils of patients with CVI are primed and/or activated because they are able to release higher amount of superoxide, lysosomal enzymes and express elevated number of adhesion molecules. It may serve as one of the important evidences of an inflammatory mechanism involved in the pathogenesis of chronic venous insufficiency. (Tab. 3, Ref. 27.)
Authors:
V Stvrtinova; E Jahnova; S Weissova; M Horvathova; M Ferencik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  102     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2001  
Date Detail:
Created Date:  2001-11-29     Completed Date:  2001-12-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Affiliation:
2nd Internal Clinic, Faculty of Medicine, Comenius University, Mickiewiczova 13, SK-813 69 Bratislava, Slovakia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cell Adhesion Molecules / metabolism
Chronic Disease
Female
Glucuronidase / metabolism
Humans
Inflammation Mediators / metabolism*
Leg / blood supply*
Male
Middle Aged
Muramidase / metabolism
Neutrophils / metabolism*
Pancreatic Elastase / metabolism
Peroxidase / metabolism
Superoxides / metabolism
Venous Insufficiency / metabolism*
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Inflammation Mediators; 11062-77-4/Superoxides; EC 1.11.1.7/Peroxidase; EC 3.2.1.17/Muramidase; EC 3.2.1.31/Glucuronidase; EC 3.4.21.36/Pancreatic Elastase

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