Document Detail

Inflammatory markers increase following exposure to radiographic contrast media.
MedLine Citation:
PMID:  14510756     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Increased levels of markers of systemic inflammation have been noted in patients following coronary angiographic procedures. The purpose of the present study was to examine the influence of the type of the angiographic procedure as well as the type of radiographic contrast media (RCM) on markers of inflammation. MATERIAL AND METHODS: Thirty-seven patients undergoing diagnostic or interventional coronary angiographic procedures were randomly assigned to receive one of three RCM - an ionic low osmolar agent; a non-ionic, iso-osmotic agent; or a non-ionic, low osmolar agent. Sera were analyzed at baseline (prior to receiving RCM), and at 2, 6 and 24 h thereafter for interleukin (IL)-6 and soluble receptors for tumor necrosis factor alpha (TNFalpha)-1 and TNFalpha- 2. RESULTS: Statistically significant increases over time in each RCM group were noted for IL-6 and both TNFalpha receptors. Comparable increases in inflammatory markers were observed in patients undergoing diagnostic angiography and in patients undergoing an associated coronary intervention. While these markers increased following exposure to both ionic and non-ionic RCM, there was a consistent trend towards lessened marker release with non-ionic RCM. CONCLUSION: Both diagnostic and interventional coronary angiographic procedures are associated with an increase in serum inflammatory markers. While both ionic and non-ionic RCM are associated with increases in serum inflammatory markers, this increase may be attenuated with non-ionic RCM.
W K Laskey; J Gellman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  44     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2003-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  498-503     Citation Subset:  IM    
Cardiac Catheterization Laboratory, Division of Cardiology, University of Maryland Medical System, Baltimore, MD, USA.
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MeSH Terms
Contrast Media / pharmacology*
Double-Blind Method
Interleukin-6 / blood*
Iohexol / pharmacology*
Ioxaglic Acid / pharmacology*
Middle Aged
Pilot Projects
Receptors, Tumor Necrosis Factor / blood*,  drug effects*
Triiodobenzoic Acids / pharmacology*
Reg. No./Substance:
0/Contrast Media; 0/Interleukin-6; 0/Receptors, Tumor Necrosis Factor; 0/Triiodobenzoic Acids; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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