| Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. | |
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MedLine Citation:
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PMID: 15155869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence strongly implicates the inflammatory response to intrauterine infection in the pathogenesis of neonatal brain and lung injury. We hypothesized that lung and brain injury in preterm infants occurs during a common developmental window of vulnerability as the result of an inflammatory response in different compartments. To determine whether inflammatory markers in these compartments are associated with bronchopulmonary dysplasia (BPD) or cranial ultrasound (CUS) abnormalities in infants <33 wk gestation age (GA) and <1501 g birth weight, we analyzed placental pathology and serum and cerebrospinal fluid (CSF) IL-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha) concentrations in 276 infants. Logistic regressions were performed stratified by GA. Histologic chorioamnionitis was significantly associated with BPD in infants </=28 wk GA (OR 3.6, p = 0.027). Maternal stage of chorioamnionitis significantly correlated with severity of BPD. Presence of a fetal inflammatory response indicated by fetal vasculitis or elevated cytokines was not associated with the development of BPD. Serum IL-6 >/=17 pg/mL was associated with an abnormal CUS in infants >28 wk GA (OR 3.36, p = 0.023) but not </=28 wk GA. CSF concentrations of IL-6 >/=6.5 pg/mL and TNF-alpha >/=3 pg/mL were associated with abnormal CUS in infants </=28 wk GA (IL-6 OR 3.0; TNF-alpha OR 3.5; p < 0.05 each case) but not >/=28 wk GA. These data suggest that in infants </=28 wks GA, BPD may be initiated by inflammatory mediators in amniotic fluid, but brain injury may involve variations in the systemic inflammatory response. |
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Authors:
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Rose M Viscardi; Catherine K Muhumuza; Andres Rodriguez; Karen D Fairchild; Chen-Chih J Sun; George W Gross; Andrew B Campbell; P David Wilson; Lisa Hester; Jeffrey D Hasday |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 55 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-24 Completed Date: 2004-12-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 1009-17 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. rviscard@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Injuries
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blood*,
cerebrospinal fluid*,
etiology Bronchopulmonary Dysplasia / blood*, cerebrospinal fluid*, etiology Chorioamnionitis / blood, cerebrospinal fluid, complications Cohort Studies Female Fetal Blood / metabolism* Humans Infant, Newborn Infant, Premature Inflammation Mediators / cerebrospinal fluid, metabolism* Interleukin-1 / blood, cerebrospinal fluid Interleukin-6 / blood, cerebrospinal fluid Male Pregnancy Pregnancy Outcome Risk Factors Tumor Necrosis Factor-alpha / cerebrospinal fluid, metabolism Uterus / blood supply, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL71113-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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