Document Detail


Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features.
MedLine Citation:
PMID:  22405656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis appear to have increases in pro-inflammatory cytokines. Patients characterized by primary, enduring negative symptoms (deficit symptoms) differ from patients without such features with regard to course of illness, treatment response, risk factors and metabolic disturbances. We hypothesized that they would also differ on concentrations of the inflammatory markers interleukin-6 (IL6) and C-reactive protein (CRP). Newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis were categorized into deficit (N=20) and nondeficit (N=42) groups, and were matched on age, gender, body mass index, smoking, cortisol level, socioeconomic status, and the severity of psychotic symptoms. Fasting concentrations of IL6 were significantly higher in deficit (mean [S.D.]) (8.0 pg/ml [12.7]) than nondeficit patients (0.3 pg/ml [1.3]). CRP levels were also significantly higher in the deficit patients (0.3 mg/dl [0.4]) vs. (0.2 mg/dl [0.4]), respectively. In contrast, 2-h glucose concentrations (2HG) in a glucose tolerance test were lower in the deficit than the nondeficit group. Our results show a double dissociation with regard to glucose intolerance and inflammation: the deficit group has greater inflammation, but less severe glucose intolerance. These results provide further evidence for the validity of the deficit/nondeficit categorization.
Authors:
Clemente Garcia-Rizo; Emilio Fernandez-Egea; Cristina Oliveira; Azucena Justicia; Miguel Bernardo; Brian Kirkpatrick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-08
Journal Detail:
Title:  Psychiatry research     Volume:  198     ISSN:  1872-7123     ISO Abbreviation:  Psychiatry Res     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-04-23     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Glucose / metabolism
C-Reactive Protein / metabolism*
Fasting / blood
Female
Glucose Tolerance Test / statistics & numerical data
Humans
Inflammation Mediators / blood*
Interleukin-6 / metabolism*
Male
Middle Aged
Psychotic Disorders / blood,  diagnosis*
Grant Support
ID/Acronym/Agency:
R01 DK069265/DK/NIDDK NIH HHS; R01 DK069265-01A1/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Inflammation Mediators; 0/Interleukin-6; 9007-41-4/C-Reactive Protein
Comments/Corrections
Erratum In:
Psychiatry Res. 2013 Dec 30;210(3):1329

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