Document Detail


Inflammatory markers are not associated with outcomes following elective external cardioversion.
MedLine Citation:
PMID:  16257462     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Electrical cardioversion is a common modality of therapy for persistent atrial fibrillation. Unfortunately even if the cardioversion is initially successful many patients revert to atrial fibrillation. It has been proposed that there may be an inflammatory component to this arrhythmia. It is interesting to speculate that this may have a role in determining the outcome following elective cardioversion. METHODS: The study group consisted of 81 patients with persistent atrial fibrillation undergoing elective external cardioversion. Blood samples were taken immediately prior to the procedure. Soluble E-Selectin, P-Selectin, intra-cellular adhesion molecule and vascular cell adhesion molecule were assayed using a commercially available enzyme linked immunosorbent assay technique (R&D systems) and high sensitivity C reactive protein was measured by rate nephelometry. Patients were reviewed at 8 weeks and bloods were taken at this time. RESULTS: At baseline patients who had an unsuccessful cardioversion (n=15) were compared to those who had a successful cardioversion (n=66). Thirty-two patients of the 66 initially successful patients reverted to atrial fibrillation during the follow-up period. There was no difference in the levels of baseline serum inflammatory markers measured between those with an unsuccessful cardioversion and those who were successful. When the group who reverted to atrial fibrillation were compared to those who remained in sinus rhythm again there was no difference in the levels of serum markers measured at baseline. CONCLUSION: There was no association between maintenance of sinus rhythm following cardioversion and serum inflammatory markers.
Authors:
John Cosgrave; J Brendan Foley; Khan Bahadur; Kathleen Bennett; Peter Crean; Michael J Walsh
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-28
Journal Detail:
Title:  International journal of cardiology     Volume:  110     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  373-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, EMO Centro Cuore Columbus, Via M. Buonarotti 48, 20145, Milano, Italy. cosgravejohn@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Atrial Fibrillation / blood*,  pathology,  therapy*
Biological Markers / blood
Electric Countershock*
Female
Follow-Up Studies
Humans
Inflammation / blood
Male
Middle Aged
Treatment Outcome
Chemical
Reg. No./Substance:
0/Biological Markers

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