Document Detail


Inflammatory marker expression and its implication in Korean ischemic stroke patients.
MedLine Citation:
PMID:  18094576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ischemic stroke is a complex condition influenced by many factors. Previous studies have demonstrated that inflammatory markers might play a role in such vascular diseases. Therefore the purpose of this study was to compare the expression of inflammatory markers in Korean ischemic stroke patients and to investigate their relationship to APOE polymorphism.
METHODS: The patient group consisted of 275 patients with large artery atherosclerosis (LAA, n=169) and small artery occlusion (SAO, n=106). One hundred and nineteen age matched healthy subjects were recruited as the control group. Serum levels of three inflammatory markers (matrix metalloproteinase, MMP-9; tissue inhibitor of metalloproteinase-1, TIMP-1; and high-sensitivity C-reactive protein, hs-CRP) were measured in each patient by using commercially available kits. Comparison of clinical risk factors, inflammatory marker levels, and APOE genotypes between the stroke patient group and control group and between the two patient subgroups was assessed.
RESULTS: Comparison of the stroke group to control group showed significantly elevated levels of circulating MMP-9 (P<0.01) and hs-CRP (P=0.01). Comparison between the individual subgroups revealed a significantly higher level of only TIMP-1 in the LAA subgroup compared to the SAO subgroup (P<0.01). There was no significant difference in inflammatory marker levels among each allele carrier.
CONCLUSIONS: The present study revealed the obvious tendency of increased circulating inflammatory markers in the patients with acute ischemic attack, especially MMP-9 and hs-CRP. Our observations suggest that measurement of serum MMP-9, TIMP-1, and hs-CRP levels may be useful in the diagnosis of ischemic stroke patients.
Authors:
Su Yon Park; Meoung Hee Kim; So Young Kang; Jin Tae Suh; Woo In Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Korean journal of laboratory medicine     Volume:  27     ISSN:  1598-6535     ISO Abbreviation:  Korean J Lab Med     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-10-17     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101322822     Medline TA:  Korean J Lab Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoproteins E / genetics*
Biological Markers / blood
Brain Ischemia / complications,  diagnosis*
C-Reactive Protein / analysis
Carotid Artery Diseases / complications
Female
Genotype
Humans
Inflammation Mediators / blood*
Korea
Male
Matrix Metalloproteinase 9 / blood
Middle Aged
Polymorphism, Genetic
Stroke / diagnosis*,  etiology,  immunology
Tissue Inhibitor of Metalloproteinase-1 / blood
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Biological Markers; 0/Inflammation Mediators; 0/Tissue Inhibitor of Metalloproteinase-1; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9

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