Document Detail

Inflammatory and growth factor response to continuous and intermittent exercise in youth with cystic fibrosis.
MedLine Citation:
PMID:  22071215     Owner:  NLM     Status:  Publisher    
BACKGROUND: Children with cystic fibrosis (CF) tend to suffer from chronic systemic inflammation and may have impaired growth associated with muscle catabolism. Therefore, investigating which type of exercise can elicit an anabolic response with minimal inflammation is of clinical value. METHODS: Twelve children with CF (mean±SD; age: 14.7±2.3years, predicted FEV(1): 90.0±21.6%) and biological age-matched controls (age: 13.9±2.1years) completed moderate-intensity, continuous exercise (MICE) and high-intensity, intermittent exercise (HIIE) on separate days. During each exercise, blood was drawn at various time points and analyzed for immune cells, inflammatory cytokines, and growth mediators. RESULTS: At rest, children with CF had higher concentrations of neutrophils and IL-6 compared with controls. In children with CF, HIIE did not affect immune cell subsets or cytokines: TNF-α, IL-6, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK). All immune cell subsets and IL-6 increased significantly with MICE in both groups. Growth hormone (GH) increased with both types of exercise, with a greater change from rest during MICE. CONCLUSIONS: HIIE was a sufficient stimulus to increase GH in children with CF, without affecting systemic inflammation.
Thanh Nguyen; Joyce Obeid; Hilde E Ploeger; Tim Takken; Linda Pedder; Brian W Timmons
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-7
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  -     ISSN:  1873-5010     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
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