| Inflammatory and functional effects of increasing asthma treatment with formoterol or double dose budesonide. | |
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MedLine Citation:
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PMID: 18632258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adding a long-acting beta(2)-agonist to inhaled corticosteroids (ICS) for asthma treatment is better than increasing ICS dose in improving clinical status, although there is no consensus about the impact of this regimen on inflammation. In this double-blind, randomized, parallel group study, asthmatics with moderate to severe disease used budesonide (400 mcg/day) for 5 weeks (run-in period); then they were randomized to use budesonide (800 mcg/day--BUD group) or budesonide plus formoterol (400 mcg and 24 mcg/day, respectively--FORMO group) for 9 weeks (treatment period). Home PEF measurements, symptom daily reporting, spirometry, sputum induction (for differential cell counts and sputum cell cultures), and hypertonic saline bronchial challenge test were performed before and after treatments. TNF-alpha, IL-4 and eotaxin-2 levels in the sputum and cell culture supernatants were determined. Morning and night PEF values increased in the FORMO group during the treatment period (p<0.01), from 435+/-162 to 489+/-169 and 428+/-160 to 496+/-173 L/min, respectively. The rate of exacerbations in the FORMO group was lower than in the BUD group (p<0.05). Neutrophil counts in sputum increased in both groups (p<0.05) and leukocyte viability after 48 h-culture increased in the FORMO group (p<0.05). No other parameter changed significantly in either group. This study showed that adding formoterol to budesonide improved home PEF and provided protection from exacerbations, although increase of leukocyte viability in cell culture may be a matter of concern and needs further investigation. |
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Authors:
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Marcelo B Menezes; Antônio L Teixeira; João Terra Filho; Elcio O Vianna |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-07-15 |
Journal Detail:
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Title: Respiratory medicine Volume: 102 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-02 Completed Date: 2009-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1385-91 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of S. Paulo Medical School at Ribeirão Preto, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenergic beta-Agonists / therapeutic use Adult Asthma / drug therapy*, immunology, physiopathology Bronchodilator Agents / administration & dosage*, therapeutic use Budesonide / administration & dosage*, therapeutic use Cytokines / immunology Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Ethanolamines / administration & dosage*, therapeutic use Female Glucocorticoids / therapeutic use Humans Lung / physiopathology Male Middle Aged Peak Expiratory Flow Rate Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Bronchodilator Agents; 0/Cytokines; 0/Ethanolamines; 0/Glucocorticoids; 51333-22-3/Budesonide; 73573-87-2/formoterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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