Document Detail


Inflammatory fibroid polyp of the gallbladder bearing a platelet-derived growth factor receptor alpha mutation.
MedLine Citation:
PMID:  23627457     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The inflammatory fibroid polyp (IFP) is a benign lesion occurring in the digestive tract, mostly in the stomach and small bowel, composed of fibrovascular tissue infiltrated by inflammatory cells including eosinophils and mastocytes. Its pathogenesis has been controversial (reactive versus neoplastic). The recent finding of mutations in platelet-derived growth factor receptor α (PDGFRA) in most gastric and small intestinal IFPs supported their neoplastic etiology, moreover helping in their differential diagnosis. In the only gallbladder IFP reported so far, the diagnosis was based on morphologic and immunohistochemical grounds, which in current standards would probably be considered not fully conclusive. Conversely, the gallbladder IFP we report shows typical pathologic features supported by a PDGFRA mutation, similar to its usual gastric and small intestinal counterparts, constituting the first report of an unequivocal IFP at gallbladder level. Thus, IFPs must be considered in the differential diagnosis of gallbladder mesenchymal masses, and genetic analysis of PDGFRA is a helpful tool for this purpose.
Authors:
Maurizio Martini; Luisa Santoro; Pietro Familiari; Guido Costamagna; Riccardo Ricci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  137     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  721-4     Citation Subset:  AIM; IM    
Affiliation:
From the Pathology Department (Drs Martini, Santoro, and Ricci) and the Digestive Endoscopy Department (Drs Familiari and Costamagna), Catholic University, Rome, Italy.
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