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Inflammatory factor increases cyclooxygenase expression on the development of no-reflow.
MedLine Citation:
PMID:  25399887     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. Increased level of inflammatory factors including C-reactive protein (CRP) levels in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) may affect myocardial perfusion. However mechanisms that no-reflow increases in inflammation stress on the no-reflow phenomenon of AMI are not clear. The purpose of current study was to determine the effects and molecular mechanisms of CRP on the expression of cyclooxygenase (COX) on the development of no-reflow. We first demonstrated inflammatory factors CRP and interleukin-6 (IL-6) were significantly increased in no-reflow patients, suggesting that inflammatory factors play an important role on the development of no-reflow. The next we research the mechanisms by generating the animal model mimicking the no-reflow phenomenon. Compared with the normal reflow rats, COX1 and COX2 were both increased in no-reflow rats. And COX inhibitor indomethacin significantly reduced the no-reflow area. In addition, human coronary artery endothelial cells (HCAEC) were treated with CRP at clinically relevant concentrations for different durations. CRP significantly increased COX1 and COX2 protein levels in a time and concentration-dependent manner. The extracellular signal-regulated kinase (ERK) and Jun N-terminal kinase (JNK) of CRP-treated HCAEC cultures were also activated. Furthermore, ERk inhibitor and JNK inhibitor blocked CRP-induced COX1 and COX2 expression. Together, our data suggested that inflammatory factors CRP can promote the no-reflow development by increasing COX1 and COX2 expression which is partially regulated by ERK and JNK activity. This article is protected by copyright. All rights reserved.
Authors:
Qibin Jiao; Qiang Ke; Weiwei Li; Meihua Jin; Yan Luo; Linan Zhang; Dong Yang; Xingwei Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-15
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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