Document Detail

Inflammatory effects of ozone in the upper airways of subjects with asthma.
MedLine Citation:
PMID:  8173759     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine whether exposure to ozone causes inflammatory or functional changes in the upper or lower airways of asthmatic and nonasthmatic individuals. Ten asthmatic and eight nonasthmatic subjects were exposed to clean air, 120 ppb ozone, or 240 ppb ozone for 90 min during intermittent moderate exercise using a head dome exposure system. Pulmonary function tests, posterior rhinomanometry, and nasal lavage were performed before and after exposure. Leukocyte counts and chemotactic factors leukotriene B4 (LTB4), platelet-activating factor (PAF), and interleukin-8 (IL-8) were analyzed from nasal lavage fluid. In subjects with asthma, a significant increase (p < 0.05) in the number of white blood cells in lavage fluid was detected both immediately and 24 h after exposure to 240 ppb ozone, as was a significant increase in epithelial cells immediately after exposure (p < 0.05). No significant cellular changes were seen in nonasthmatic subjects. A significant correlation was observed between IL-8 and white blood cells counts after exposure to 240 ppb ozone (r = 0.76) in asthmatic subjects. No significant changes in pulmonary or nasal function or biochemical mediators were found in either the asthmatic or nonasthmatic subjects. These data indicate that asthmatic individuals are more sensitive to the acute inflammatory effects of ozone than nonasthmatic individuals.
D E McBride; J Q Koenig; D L Luchtel; P V Williams; W R Henderson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  149     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-07     Completed Date:  1994-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1192-7     Citation Subset:  AIM; IM    
Department of Environmental Health, University of Washington, Seattle 98195.
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MeSH Terms
Asthma / metabolism,  pathology*
Histamine / analysis
Interleukin-8 / analysis
Leukocyte Count
Leukotriene B4 / analysis
Nasal Lavage Fluid / chemistry,  cytology
Ozone / adverse effects*
Platelet Activating Factor / analysis
Respiratory Mechanics
Respiratory System / pathology*
Grant Support
Reg. No./Substance:
0/Interleukin-8; 0/Platelet Activating Factor; 10028-15-6/Ozone; 51-45-6/Histamine; 71160-24-2/Leukotriene B4

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