Document Detail

Inflammatory cytokines correlated with clinical outcome of temporomandibular joint irrigation in patients with chronic closed lock.
MedLine Citation:
PMID:  17052634     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study investigated the correlation of clinical outcomes of temporomandibular joint (TMJ) irrigation with the occurrence and concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8, IL-12, and IL-10 in the washed-out synovial fluid (SF) in patients with chronic closed lock (CCL) of the TMJ. STUDY DESIGN: Thirty-six patients underwent a visually guided TMJ irrigation (VGIR). SF samples were collected immediately before VGIR. The patients were divided into either successful (s-group; n = 25) or unsuccessful groups (u-group; n = 11). The detection rates and concentrations of each cytokine per milligram of total protein in the SF were measured, and then compared between the s- and u-groups. RESULTS: All of the investigated cytokines were detectable with various rates, concentrations, and combination patterns. The detection rate and concentrations of IL-6 were significantly higher in the u-group, and those of IL-10 were significantly higher in the s-group. CONCLUSIONS: The investigated cytokines were suggested to be involved in the pathophysiology of TMJ CCL. The results also suggest that IL-6 in the SF is an indicator of an unsuccessful outcome, and that IL-10 is a significant predictor of a successful outcome of TMJ irrigation for CCL.
Yoshiki Hamada; Toshirou Kondoh; Anders B Holmlund; Matsuo Yamamoto; Akihisa Horie; Tomoyuki Saito; Ko Ito; Kanichi Seto; Hideki Sekiya
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Publication Detail:
Type:  Journal Article     Date:  2006-07-18
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  102     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2006-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  596-601     Citation Subset:  D; IM    
First Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan. <>
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MeSH Terms
Age Factors
Arthroscopy / methods
Chronic Disease
Dislocations / metabolism,  surgery
Interleukin-1 / biosynthesis
Interleukin-10 / biosynthesis*
Interleukin-12 / biosynthesis
Interleukin-6 / biosynthesis*
Interleukin-8 / biosynthesis
Middle Aged
Osteoarthritis / metabolism*,  surgery
Range of Motion, Articular
Statistics, Nonparametric
Synovial Fluid / chemistry
Temporomandibular Joint Disorders / metabolism*,  surgery*
Treatment Outcome
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12

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