| Inflammatory cytokines correlated with clinical outcome of temporomandibular joint irrigation in patients with chronic closed lock. | |
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MedLine Citation:
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PMID: 17052634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study investigated the correlation of clinical outcomes of temporomandibular joint (TMJ) irrigation with the occurrence and concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8, IL-12, and IL-10 in the washed-out synovial fluid (SF) in patients with chronic closed lock (CCL) of the TMJ. STUDY DESIGN: Thirty-six patients underwent a visually guided TMJ irrigation (VGIR). SF samples were collected immediately before VGIR. The patients were divided into either successful (s-group; n = 25) or unsuccessful groups (u-group; n = 11). The detection rates and concentrations of each cytokine per milligram of total protein in the SF were measured, and then compared between the s- and u-groups. RESULTS: All of the investigated cytokines were detectable with various rates, concentrations, and combination patterns. The detection rate and concentrations of IL-6 were significantly higher in the u-group, and those of IL-10 were significantly higher in the s-group. CONCLUSIONS: The investigated cytokines were suggested to be involved in the pathophysiology of TMJ CCL. The results also suggest that IL-6 in the SF is an indicator of an unsuccessful outcome, and that IL-10 is a significant predictor of a successful outcome of TMJ irrigation for CCL. |
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Authors:
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Yoshiki Hamada; Toshirou Kondoh; Anders B Holmlund; Matsuo Yamamoto; Akihisa Horie; Tomoyuki Saito; Ko Ito; Kanichi Seto; Hideki Sekiya |
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Publication Detail:
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Type: Journal Article Date: 2006-07-18 |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 102 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-20 Completed Date: 2006-10-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 596-601 Citation Subset: D; IM |
Affiliation:
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First Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan. hamada-y@tsurumi-u.ac.jp <hamada-y@tsurumi-u.ac.jp> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Arthroscopy / methods Chronic Disease Dislocations / metabolism, surgery Female Humans Interleukin-1 / biosynthesis Interleukin-10 / biosynthesis* Interleukin-12 / biosynthesis Interleukin-6 / biosynthesis* Interleukin-8 / biosynthesis Irrigation Male Middle Aged Osteoarthritis / metabolism*, surgery Prognosis Range of Motion, Articular Statistics, Nonparametric Synovial Fluid / chemistry Temporomandibular Joint Disorders / metabolism*, surgery* Treatment Outcome Tumor Necrosis Factor-alpha / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12 |
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