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Inflammatory cytokines at admission-Independent prognostic markers in patients with acute coronary syndrome and hyperglycaemia.
MedLine Citation:
PMID:  22356568     Owner:  NLM     Status:  In-Data-Review    
Background: The clinical significance of inflammatory cytokines as independent prognostic markers in patients with acute coronary syndrome (ACS) and hyperglycaemia remains uncertain. Aim: To determine the value of inflammatory biomarkers as independent prognostic indicators and their relation with hyperglycaemia in ACS patients. Methods: TNF-α and hsCRP were defined 48 h after admission and indicators for hyperglycaemia were calculated in 256 consecutive patients with ACS. A correlation analysis with standard clinical variables-EF, maximum CK, CK-MB, troponin and different indices for hyperglycaemia was performed. Patients were followed up for 12 months. Results: Baseline TNF-α correlated neither to EF, nor to the enzymes for myocardial necrosis (P> 0.05). In contrast, hsCRP correlated negatively with EF (P= 0.001) and positively with maximum CK, CK-MB, troponin (P= 0.0001) irrespectively of the glucose status. TNF-α was associated with fasting glycaemia, HGI and TAG (P= 0.033/0.041/0.018) and hsCRP-with indicators for acute, persistent and chronic glycaemia in all patients. Moreover, hsCRP was an independent marker for six-month survival (P= 0.024). TAG was a stronger six-month survival predictor than hsCRP (P= 0.010/0.024). Conclusion: hsCRP and TNF-α have clinical significance regardless of the glucose metabolic status. hsCRP is an independent marker for six-month survival. TAG is the better predictor for poor outcome than hsCRP.
Zheyna Vlaeva Cherneva; Stefan Veselinov Denchev; Mariana Vasileva Gospodinova; Adelina Cakova; Radostina Vlaeva Cherneva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  14     ISSN:  1748-295X     ISO Abbreviation:  Acute Card Care     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
University Hospital 'Aleksandrovska', Clinic of Cardiology , Sofia , Bulgaria.
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