| Inflammatory cytokines at admission-Independent prognostic markers in patients with acute coronary syndrome and hyperglycaemia. | |
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MedLine Citation:
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PMID: 22356568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The clinical significance of inflammatory cytokines as independent prognostic markers in patients with acute coronary syndrome (ACS) and hyperglycaemia remains uncertain. Aim: To determine the value of inflammatory biomarkers as independent prognostic indicators and their relation with hyperglycaemia in ACS patients. Methods: TNF-α and hsCRP were defined 48 h after admission and indicators for hyperglycaemia were calculated in 256 consecutive patients with ACS. A correlation analysis with standard clinical variables-EF, maximum CK, CK-MB, troponin and different indices for hyperglycaemia was performed. Patients were followed up for 12 months. Results: Baseline TNF-α correlated neither to EF, nor to the enzymes for myocardial necrosis (P> 0.05). In contrast, hsCRP correlated negatively with EF (P= 0.001) and positively with maximum CK, CK-MB, troponin (P= 0.0001) irrespectively of the glucose status. TNF-α was associated with fasting glycaemia, HGI and TAG (P= 0.033/0.041/0.018) and hsCRP-with indicators for acute, persistent and chronic glycaemia in all patients. Moreover, hsCRP was an independent marker for six-month survival (P= 0.024). TAG was a stronger six-month survival predictor than hsCRP (P= 0.010/0.024). Conclusion: hsCRP and TNF-α have clinical significance regardless of the glucose metabolic status. hsCRP is an independent marker for six-month survival. TAG is the better predictor for poor outcome than hsCRP. |
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Authors:
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Zheyna Vlaeva Cherneva; Stefan Veselinov Denchev; Mariana Vasileva Gospodinova; Adelina Cakova; Radostina Vlaeva Cherneva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acute cardiac care Volume: 14 ISSN: 1748-295X ISO Abbreviation: Acute Card Care Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101276603 Medline TA: Acute Card Care Country: England |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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University Hospital 'Aleksandrovska', Clinic of Cardiology , Sofia , Bulgaria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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