| Inflammatory cytokine profiles in the tears of thyroid-associated ophthalmopathy. | |
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MedLine Citation:
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PMID: 22124787 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To investigate the levels of seven inflammatory cytokines and one chemokine in tears of patients with thyroid-associated ophthalmopathy (TAO) and asymptomatic control subjects, and determine the correlations between tear inflammatory mediators and clinical parameters. METHODS: Prospective observational cohort study. The study involved 21 patients with TAO and ten asymptomatic controls. TAO patients were divided into active TAO and inactive TAO on the basis of 7-point modified formulation of the clinical activity score (CAS). Ocular Surface Disease Index (OSDI) score, tear film break-up time (BUT) was obtained, and the Schirmer test and fluorescein staining were performed in all participants. Ten microliters of tears were collected for analysis the concentrations of interleukin (IL)-1β, IL-2, IL-6, IL-10, IL-17 interferon (IFN)-γ, tumor necrosis factor (TNF)-α and one chemokine (IL-8) by multiplex bead analysis. RESULTS: Fluorescein staining scores were higher, BUT scores were shorter, and Schirmer test scores were lower in patients with active TAO and inactive TAO than in control subjects. IL-1β, IL-6, and IL-8 concentrations in tears were significantly higher in active TAO than inactive TAO and the controls. TNF-α concentration was significantly higher in both active and inactive TAO compared with the controls. IL-17 was significantly higher in active TAO than the controls, and the level of IL-2 was significantly higher in inactive TAO compared with the controls. There were significantly positive correlations between tear IL-1β, IL-6 and IL-8 levels and CAS in TAO. No significant correlations were found between other cytokine concentrations and clinical parameters in TAO. CONCLUSIONS: The differences of tear inflammatory cytokines between patients with active and inactive TAO indicated that orbital inflammation may be involved in the ocular surface damage of TAO. |
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Authors:
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Danping Huang; Nuo Xu; Yiyue Song; Peijuan Wang; Huasheng Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-30 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Volume: - ISSN: 1435-702X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, hdp828@yahoo.com.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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