| Inflammatory cytokine mRNA in monocytes is modified by a recombinant (SP-C)-based surfactant and porcine surfactant. | |
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MedLine Citation:
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PMID: 19649338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory distress syndrome (RDS) is mainly caused by a deficiency of surfactant in structurally immature lungs. Therapy for RDS consists of mechanical ventilation and administration of exogenous surfactant. Animal-derived surfactant preparations that are used to treat newborn infants show inhibition of proinflammatory cytokines. There are no data available concerning the effects of the new generation of surfactants. In the present study, the effects of an animal-derived surfactant (Curosurf) and a synthetic surfactant (Venticute) on lipopolysaccharide (LPS)-induced inflammation were tested in human monocyte THP-1 cells. The effects were measured as changes in messenger RNA (mRNA) expression of the chemokine interleukin-8 (IL-8), proinflammatory TNF-alpha and the anti-inflammatory IL-10 cytokine. Both surfactant preparations inhibited the LPS-induced increase in TNF-alpha expression. A comparison of both preparations revealed a similar effect on IL-10 expression. However, IL-10 expression was higher after incubation with Venticute. Curosurf increased IL-8 expression at higher concentrations, but Venticute had no effect. The anti-inflammatory effect of an animal-derived surfactant and a new-generation synthetic surfactant preparation may influence postnatal pulmonary inflammation. |
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Authors:
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Andreas Wemhöner; Mario Rüdiger; Ludwig Gortner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods and findings in experimental and clinical pharmacology Volume: 31 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-11-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: Spain |
Other Details:
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Languages: eng Pagination: 317-23 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved. |
Affiliation:
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Medical University Innsbruck, Department of Pediatrics and Neonatology, Austria. andreas.wemhoener@uniklinikumdresden.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Products
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pharmacology* Cells, Cultured Cytokines / genetics* Humans Interleukin-10 / biosynthesis Interleukin-8 / genetics Lipopolysaccharides / pharmacology Monocytes / metabolism* Phospholipids / pharmacology* RNA, Messenger / analysis* Recombinant Proteins / pharmacology* Tumor Necrosis Factor-alpha / genetics |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Cytokines; 0/Interleukin-8; 0/Lipopolysaccharides; 0/Phospholipids; 0/RNA, Messenger; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha; 0/Venticute; 129069-19-8/poractant alfa; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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