Document Detail

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE).
MedLine Citation:
PMID:  18703173     Owner:  NLM     Status:  MEDLINE    
Deficiencies in the recognition and phagocytosis of dead and dying cells have been shown to be one of the main alterations in patients with systemic lupus erythematosus (SLE). Cellular as well as humoral elements play an important role in the clearance of apoptotic and necrotic cells. Non-ingested nuclear material may provide survival signals for autoreactive B-cells and consequently antibodies directed against nuclear structures will be produced. In healthy individuals, nuclear fragments are not phagocytosed in whole blood. Instead, they are mainly degraded by the action of plasma DNases and complement factors. In contrast, the uptake of nuclear fragments by blood-borne phagocytes is increased in most patients with SLE. The phagocytosis of this kind of prey, which might be opsonised by autoantibodies, may contribute to the maintenance of inflammatory responses in SLE.
C Janko; C Schorn; G E Grossmayer; B Frey; M Herrmann; U S Gaipl; L E Munoz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-12
Journal Detail:
Title:  Autoimmunity reviews     Volume:  8     ISSN:  1873-0183     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Institute for Clinical Immunology and Rheumatology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
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MeSH Terms
Antibody Formation
Antibody-Dependent Cell Cytotoxicity
Antigens, Nuclear / immunology,  metabolism*
Apoptosis / immunology*
Complement System Proteins / metabolism
DNA Fragmentation
Immunity, Cellular
Lupus Erythematosus, Systemic / immunology*
Phagocytes / immunology,  metabolism*,  pathology
Phagocytosis / immunology*
Reg. No./Substance:
0/Antigens, Nuclear; 9007-36-7/Complement System Proteins

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