| Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). | |
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MedLine Citation:
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PMID: 18703173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deficiencies in the recognition and phagocytosis of dead and dying cells have been shown to be one of the main alterations in patients with systemic lupus erythematosus (SLE). Cellular as well as humoral elements play an important role in the clearance of apoptotic and necrotic cells. Non-ingested nuclear material may provide survival signals for autoreactive B-cells and consequently antibodies directed against nuclear structures will be produced. In healthy individuals, nuclear fragments are not phagocytosed in whole blood. Instead, they are mainly degraded by the action of plasma DNases and complement factors. In contrast, the uptake of nuclear fragments by blood-borne phagocytes is increased in most patients with SLE. The phagocytosis of this kind of prey, which might be opsonised by autoantibodies, may contribute to the maintenance of inflammatory responses in SLE. |
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Authors:
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C Janko; C Schorn; G E Grossmayer; B Frey; M Herrmann; U S Gaipl; L E Munoz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-08-12 |
Journal Detail:
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Title: Autoimmunity reviews Volume: 8 ISSN: 1873-0183 ISO Abbreviation: Autoimmun Rev Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 9-12 Citation Subset: IM |
Affiliation:
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Institute for Clinical Immunology and Rheumatology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nuremberg, 91054 Erlangen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation Antibody-Dependent Cell Cytotoxicity Antigens, Nuclear / immunology, metabolism* Apoptosis / immunology* Complement System Proteins / metabolism DNA Fragmentation Humans Immunity, Cellular Lupus Erythematosus, Systemic / immunology* Necrosis Phagocytes / immunology, metabolism*, pathology Phagocytosis / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Nuclear; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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