Document Detail

Inflammatory clearance of apoptotic cells after UVB challenge.
MedLine Citation:
PMID:  17516204     Owner:  NLM     Status:  MEDLINE    
In the human body, every day billions of apoptotic cells are produced. Removal of these cells is necessary, to prevent the release of intracellular toxic constituents, and occurs very effectively via phagocytosis by (semi)-professional phagocytes. This elimination process occurs rapidly and without inflammation. In systemic lupus erythematosus (SLE) a disturbed elimination of apoptotic cells has been implicated in the induction and reactivation of the disease. Accumulation of apoptotic cells may result in autoantibody formation. A delayed, pro-inflammatory clearance is also thought to play a crucial role in the development of inflammatory lesions once the disease has manifested. One of the hallmarks of patients with SLE is the development of cutaneous lesions upon exposure to sunlight. In this review, we will focus on apoptotic cells, their elimination, and the consequences of a disturbed elimination of apoptotic cells on the development of UVB induced inflammatory skin lesions.
Marc Bijl; Esther Reefman; Pieter C Limburg; Cees G M Kallenberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Autoimmunity     Volume:  40     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Division of Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen. Groningen. The Netherlands.
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MeSH Terms
Antibody Formation / immunology,  radiation effects
Apoptosis / immunology*
Autoantibodies / immunology
Inflammation / immunology,  pathology
Lupus Erythematosus, Cutaneous / etiology,  immunology*,  pathology
Lupus Erythematosus, Systemic / complications,  immunology*
Phagocytes / immunology*,  pathology
Phagocytosis / radiation effects*
Ultraviolet Rays / adverse effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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