| Inflammatory changes parallel the early stages of Alzheimer disease. | |
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MedLine Citation:
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PMID: 17052803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer disease (AD) is the most prominent cause of dementia in the elderly. To determine changes in the AD brain that may mediate the transition into dementia, the gene expression of approximately 10,000 full-length genes was compared in mild/moderate dementia cases to non-demented controls that exhibited high AD pathology. Including this latter group distinguishes this work from previous studies in that it allows analysis of early cognitive loss. Compared to non-demented high-pathology controls, the hippocampus of AD cases with mild/moderate dementia had increased gene expression of the inflammatory molecule major histocompatibility complex (MHC) II, as assessed with microarray analysis. MHC II protein levels were also increased and inversely correlated with cognitive ability. Interestingly, the mild/moderate AD dementia cases also exhibited decreased number of T cells in the hippocampus and the cortex compared to controls. In conclusion, transition into AD dementia correlates with increased MHC II(+) microglia-mediated immunity and is paradoxically paralleled by a decrease in T cell number, suggesting immune dysfunction. |
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Authors:
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A Parachikova; M G Agadjanyan; D H Cribbs; M Blurton-Jones; V Perreau; J Rogers; T G Beach; C W Cotman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-10-18 |
Journal Detail:
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Title: Neurobiology of aging Volume: 28 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2007-11-20 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1821-33 Citation Subset: IM |
Affiliation:
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Institute for Brain Aging & Dementia, University of California, 1113 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA. aparachi@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / immunology* Brain / immunology* Cytokines / immunology* Dementia / immunology* Encephalitis / immunology* Female Gene Expression Regulation / immunology Humans |
| Grant Support | |
ID/Acronym/Agency:
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AG 020241/AG/NIA NIH HHS; AG 023173/AG/NIA NIH HHS; AG00538/AG/NIA NIH HHS; AG16573/AG/NIA NIH HHS; NS 050895/NS/NINDS NIH HHS; P01 AG000538-229001/AG/NIA NIH HHS; P30 AG19610/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
| Comments/Corrections | |
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