Document Detail

Inflammatory cells in the lungs of premature infants on the first day of life: perinatal risk factors and origin of cells.
MedLine Citation:
PMID:  8346952     Owner:  NLM     Status:  MEDLINE    
Neither the origin of leucocytes in the premature newborn airway nor their relationship to perinatal factors has been adequately determined. In order to sample airway cells, modified bronchoalveolar lavage was performed on 74 intubated infants of < 32 weeks' gestation and < 24 hours of age. Cells were counted, stained and, in a small separate group of six infants, four boys and two girls, probed for the Y chromosome with suitable control samples. Perinatal risk factors for increased airway cellularity were analysed by multiple regression. Premature rupture of membranes of more than 24 hours' duration was independently associated with increased numbers of airway leucocytes (n = 74). More than 90% of airway leucocytes from four boys with pulmonary inflammation were positive for the Y chromosome indicating that the cells were of fetal rather than maternal origin.
J Grigg; S Arnon; A Chase; M Silverman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  69     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-09-09     Completed Date:  1993-09-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  40-3     Citation Subset:  AIM; IM    
Royal Postgraduate Medical School, Hammersmith Hospital, London.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology
Fetal Membranes, Premature Rupture / pathology
In Situ Hybridization
Infant, Newborn
Infant, Premature*
Leukocyte Count
Lung / cytology*
Neutrophils / cytology*,  physiology
Risk Factors
Time Factors
Y Chromosome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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