Document Detail

Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation?
MedLine Citation:
PMID:  4015978     Owner:  NLM     Status:  MEDLINE    
The ether-linked phospholipid, Paf-acether (AGEPC) is released from a variety of inflammatory cell types and has properties consistent with those of a mediator of inflammation. We have examined the effects of locally administered Paf-acether on cellular accumulation in the skin of experimental animals and man by histological evaluation of sequential skin biopsies and quantification of accumulation of radiolabelled blood elements. In guinea-pig skin, immediate extravasation of plasma protein and intravascular accumulation of platelets and neutrophils was succeeded by a persistent mixed cellular infiltrate predominantly of neutrophils but also containing lymphocytes and histiocytes. Radiolabelling studies were consistent with these observations. Intradermal Paf-acether elicited persistent clinical and histopathological responses in human skin. The finding that Paf-acether is able to initiate cutaneous cellular accumulation may be important in the pathogenesis of inflammatory dermatoses.
C B Archer; C P Page; W Paul; J Morley; D M MacDonald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  113 Suppl 28     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-05     Completed Date:  1985-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Cell Movement
Chronic Disease
Dermatitis / metabolism,  pathology*
Guinea Pigs
Platelet Activating Factor / pharmacology,  physiology*
Skin / drug effects,  pathology*
Reg. No./Substance:
0/Platelet Activating Factor

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