| Inflammatory breast carcinoma and locally advanced breast carcinoma: characterisation with MR imaging. | |
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MedLine Citation:
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PMID: 20927653 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: This study was done to identify the typical magnetic resonance (MR) imaging findings of inflammatory breast carcinoma (IBC) in comparison with noninflammatory locally advanced breast carcinoma (LABC). MATERIALS AND METHODS: MR images of 30 patients with IBC (T4d) were compared with those of a cohort of 30 patients with LABC (T3/T4a-c). The age distribution was approximately equal in the two groups. MR images were assessed for the following features: skin thickening (>4 mm), skin oedema, architectural distortion, enhancement pattern (mass-like/non-mass-like), time-signal intensity curve (continuous-persistent type/wash-out type), skin enhancement. Fisher's exact text was used to compare MR imaging appearances of IBC and LABC (significant p value <0.05). RESULTS: Skin involvement and enhancement pattern differed between groups: skin thickening was present in 16/30 IBC (53%) vs 8/30 LABC cases (27%, p=0.06), skin oedema was present in 26/30 IBC (87%) vs 8/30 LABC (27%, p < 0.0001), and skin enhancement in 10/30 IBC (33%) vs 2/30 LABC (7%, p=0.02); non-mass-like enhancement was present in 22/30 IBC (73%) vs 12/30 LABC (40%, p=0.02). CONCLUSIONS: IBC is a distinct clinical and pathological entity resulting in typical MR imaging features. Skin changes (thickening, oedema, enhancement) related to neoplastic involvement of the dermal lymphatics are suggestive of IBC and should prompt a skin biopsy to confirm or rule out the diagnosis. |
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Authors:
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V Girardi; G Carbognin; L Camera; F Bonetti; E Manfrin; G Pollini; R Pozzi Mucelli |
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Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: La Radiologia medica Volume: 116 ISSN: 1826-6983 ISO Abbreviation: Radiol Med Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177625 Medline TA: Radiol Med Country: Italy |
Other Details:
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Languages: eng; ita Pagination: 71-83 Citation Subset: IM |
Affiliation:
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Dipartimento di Radiologia, Policlinico Universitario G.B. Rossi, P.le L.A. Scuro 10, 37134, Verona, Italy. giravero@yahoo.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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