Document Detail


Inflammatory bowel disease and serum beta-N-acetylhexosaminidase.
MedLine Citation:
PMID:  2151316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum beta-N-acetylhexosaminidase levels in 49 patients with inflammatory bowel disease (IBD; 23 patients with ulcerative colitis, 10 with Crohn's disease, and 16 with ileostomy after total proctocolectomy) as well as in healthy normal controls were determined. They were found to be significantly elevated in 91% of all patients, disregarding the state of activity of the disease. It seems most likely that activated macrophages are the source of this lysosomal hydrolase in the serum of IBD patients since other theoretical possibilities, like damaged hepatocytes or elevated serum bile acid levels, are not relevant for these patients.
Authors:
E Scapa; M Neuman; J Eshchar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Enzyme     Volume:  43     ISSN:  0013-9432     ISO Abbreviation:  Enzyme     Publication Date:  1990  
Date Detail:
Created Date:  1991-07-05     Completed Date:  1991-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1262265     Medline TA:  Enzyme     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  146-50     Citation Subset:  IM    
Affiliation:
Institute of Gastroenterology, Hepatology and Nutrition, Assaf Harofeh Medical Center, Zerifin, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Colitis, Ulcerative / enzymology*
Crohn Disease / enzymology*
Female
Humans
Ileitis / enzymology*
Liver Function Tests
Lysosomes / enzymology
Macrophages / enzymology
Male
Middle Aged
beta-N-Acetylhexosaminidases / blood*
Chemical
Reg. No./Substance:
EC 3.2.1.52/beta-N-Acetylhexosaminidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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