Document Detail

Inflammatory bowel disease and preterm delivery.
MedLine Citation:
PMID:  16043179     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. METHOD: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non-IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. RESULT: During the study period there were 48 deliveries to patients with Crohn's disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (<37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR)=2.2; 95% confidence interval (CI)=1.3-3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel-Haenszel technique (weighted OR=2.1; 95% CI 1.3-3.5 and weighted OR=2.0; 95% CI 1.2-3.5; P=0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR=2.2; 95% CI=1.1-4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR=2.0; 95% CI=1.2-3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. CONCLUSION: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.
Gabby Elbaz; Alex Fich; Amalia Levy; Gershon Holcberg; Eyal Sheiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  90     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2005-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Faculty of Health Services, Beer-Sheva, Israel.
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MeSH Terms
Case-Control Studies
Inflammatory Bowel Diseases / epidemiology*,  etiology
Israel / epidemiology
Obstetric Labor, Premature*
Pregnancy Complications / epidemiology*,  etiology
Pregnancy Outcome
Risk Factors

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