Document Detail


Inflammatory bowel disease and coronary artery disease.
MedLine Citation:
PMID:  19529899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic inflammation with the presence of excess serum acute-phase proteins, cytokines and cell adhesion molecules is increasingly being implicated in atherosclerosis. The association between inflammatory bowel disease (IBD) and coronary artery disease (CAD) is unstudied. This is a preliminary, thesis-generating cross-sectional study aimed at evaluating the presence of traditional atherosclerotic risk factors in patients with IBD and CAD compared with the control population. The medical records of 42 consecutive IBD patients with CAD from 1999 to 2005 (27 men) were reviewed for the Framingham risk factors. The Framingham risk score (FRS) is calculated based on age, sex, hypertension, diabetes and hyperlipidemia. FRS of patients with IBD and CAD was compared with the FRS of 137 age- and sex-matched (102 men) consecutive patients with CAD (controls). When the Framingham risk score adjusted for group and gender with age as a covariate, the adjusted total FRS score was higher in patients with CAD alone (10.0 [3.75]) as compared to those with; IBD and CAD: (8.1 [3.47]; p = 0.001). FRS is lower in cases (patients with IBD and CAD) when compared with the controls (CAD alone).
Authors:
Raja Shekhar R Sappati Biyyani; Nabil M Fahmy; Elizabeth Baum; Karl M Nelson; James F King
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Publication Detail:
Type:  Journal Article     Date:  2009-06-06
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  28     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-03     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  IM    
Affiliation:
Metro Health Medical Center, Cleveland, OH 44109, USA. rsappati@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / immunology,  metabolism
Atherosclerosis / epidemiology,  etiology*
Case-Control Studies
Coronary Artery Disease / complications*,  immunology
Cross-Sectional Studies
Cytokines / blood,  immunology
Female
Humans
Inflammation / blood,  complications*
Inflammatory Bowel Diseases / complications*,  immunology
Male
Middle Aged
Multivariate Analysis
Risk Factors
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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