| Inflammatory bowel disease and ankylosing spondylitis associated with cutaneous vasculitis, glomerulonephritis, and circulating IgA immune complexes. | |
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MedLine Citation:
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PMID: 2204314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients both with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) developed leucocytoclastic vasculitis of the skin and nephropathy. Immunofluorescence studies showed that there was perivascular deposition of immunoglobulin A in the skin biopsy specimens of both patients and in the renal mesangium of one patient. Serum samples of the two patients contained IgA immune complexes. The absence of previous reports on such a combination of symptoms in IBD or AS suggests that these patients may have a disease entity which is distinct from uncomplicated IBD or AS, and which may combine the immunopathological features of both underlying disorders. |
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Authors:
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A J Peeters; A W van den Wall Bake; M R Daha; F C Breeveld |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 49 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-10-09 Completed Date: 1990-10-09 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 638-40 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, University Hospital, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigen-Antibody Complex / immunology* Colitis, Ulcerative / complications, immunology* Fluorescent Antibody Technique Glomerular Mesangium / immunology Glomerulonephritis, IGA / immunology* Humans Immunoglobulin A / analysis Male Skin / immunology Spondylitis, Ankylosing / complications, immunology* Vasculitis, Leukocytoclastic, Cutaneous / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Immunoglobulin A |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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