| INFLAMMATORY BIOMARKER CHANGES AND THEIR CORRELATION WITH FRAMINGHAM CARDIOVASCULAR RISK AND LIPID CHANGES IN ANTIRETROVIRAL-NAÏVE HIV-INFECTED PATIENTS TREATED FOR 144 WEEKS WITH ABACAVIR/LAMIVUDINE/ATAZANAVIR WITH OR WITHOUT RITONAVIR IN ARIES. | |
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MedLine Citation:
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PMID: 23039030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Propensity for developing coronary heart disease (CHD) is linked with Framingham-defined cardiovascular risk factors and elevated inflammatory biomarkers. Cardiovascular risk and inflammatory biomarkers were evaluated in ARIES, a Phase IIIb/IV clinical trial in which 515 antiretroviral-naïve HIV-infected subjects initially received abacavir/lamivudine+atazanavir/ritonavir for 36 weeks. Subjects who were virologically suppressed by week 30 were randomized 1:1 at week 36 to either maintain or discontinue ritonavir for an additional 108 weeks. Framingham 10-year CHD risk scores (FRS) and risk category of <6% or 6%, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP) were assessed at baseline, week 84, and week 144. Biomarkers were stratified by FRS category. When ritonavir-boosted/non-boosted treatment groups were combined, median hsCRP did not change significantly between baseline (1.6mg/liter) and week 144 (1.4mg/liter) in subjects with FRS<6% (p=0.535), or with FRS6% (1.9mg/liter vs 2.0mg/liter, respectively; p=0.102). Median IL-6 was similar for subjects with FRS<6% (p=0.267) at baseline (1.6pg/ml) and week 144 (1.4 pg/ml) and for FRS6% (2.0pg/ml vs. 2.2pg/ml, respectively; p=0.099). Median Lp-PLA2 decreased significantly (p<0.001) between baseline (197 nmol/min/ml) and week 144 (168 nmol/min/ml) in subjects with FRS<6% and with FRS6% (238 nmol/min/ml vs. 175 nmol/min/ml, respectively; p<0.001). In conclusion, in antiretroviral-naïve subjects treated with abacavir-based therapy for 144 weeks, median inflammatory biomarker levels for hsCRP and IL-6 generally remained stable with no significant difference between baseline and week 144 for subjects with either FRS<6% or FRS6%. Lp-PLA2 median values declined significantly over 144 weeks for subjects in either FRS stratum. |
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Authors:
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Benjamin Young; Kathleen Squires; Lisa Lynn Ross; Lizette Santiago; Louis M Sloan; Henry H Zhao; Brian C Wine; Gary Edward Pakes; David A Margolis; Mark S Shaefer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Apex Research , 300 S. Jackson St, Suite 230, Denver, Colorado, United States, 80209; byoung@rockymountaincares.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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