Document Detail

Inflammatory aspects of sleep apnea and their cardiovascular consequences.
MedLine Citation:
PMID:  16466124     Owner:  NLM     Status:  MEDLINE    
Obstructive sleep apnea (OSA) is a common medical condition that occurs in a considerable percentage of the population. Substantial evidence shows that patients with OSA have an increased incidence of hypertension compared with individuals without OSA, and that OSA is a risk factor for the development of hypertension. It is established that OSA may be implicated in stroke and transient ischemic attacks. OSA is associated with coronary heart disease, heart failure, and cardiac arrhythmias. Pulmonary hypertension may be associated with OSA, especially in patients with pre-existing pulmonary disease. Although the exact cause that links OSA with cardiovascular disease is unknown, there is evidence that OSA is associated with a group of proinflammatory and prothrombotic factors that have been identified as important in the development of atherosclerosis. OSA is associated with increased daytime and nocturnal sympathetic activity. Autonomic abnormalities seen in patients with OSA include increased resting heart rate, decreased R-R interval variability, and increased blood pressure variability. Both atherosclerosis and OSA are associated with endothelial dysfunction, increased C-reactive protein, interleukin 6, fibrinogen, plasminogen activator inhibitor, and reduced fibrinolytic activity. OSA has been associated with enhanced platelet activity and aggregation. Leukocyte adhesion and accumulation on endothelial cells are common in both OSA and atherosclerosis. Clinicians should be aware that OSA may be a risk factor for the development of cardiovascular disease.
E Kasasbeh; David S Chi; G Krishnaswamy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  99     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-67; quiz 68-9, 81     Citation Subset:  AIM; IM    
Division of Allergy and Immunology, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
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MeSH Terms
Biological Markers / blood
Cardiovascular Diseases / blood,  etiology*
Cytokines / blood*
Inflammation / blood
Oxidative Stress
Risk Factors
Sleep Apnea Syndromes / blood,  complications*
Reg. No./Substance:
0/Biological Markers; 0/Cytokines
Erratum In:
South Med J. 2006 Feb;99(2):163
Summary for patients in:
South Med J. 2006 Jan;99(1):104   [PMID:  16466139 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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