| Inflammatory aspects of sleep apnea and their cardiovascular consequences. | |
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MedLine Citation:
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PMID: 16466124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obstructive sleep apnea (OSA) is a common medical condition that occurs in a considerable percentage of the population. Substantial evidence shows that patients with OSA have an increased incidence of hypertension compared with individuals without OSA, and that OSA is a risk factor for the development of hypertension. It is established that OSA may be implicated in stroke and transient ischemic attacks. OSA is associated with coronary heart disease, heart failure, and cardiac arrhythmias. Pulmonary hypertension may be associated with OSA, especially in patients with pre-existing pulmonary disease. Although the exact cause that links OSA with cardiovascular disease is unknown, there is evidence that OSA is associated with a group of proinflammatory and prothrombotic factors that have been identified as important in the development of atherosclerosis. OSA is associated with increased daytime and nocturnal sympathetic activity. Autonomic abnormalities seen in patients with OSA include increased resting heart rate, decreased R-R interval variability, and increased blood pressure variability. Both atherosclerosis and OSA are associated with endothelial dysfunction, increased C-reactive protein, interleukin 6, fibrinogen, plasminogen activator inhibitor, and reduced fibrinolytic activity. OSA has been associated with enhanced platelet activity and aggregation. Leukocyte adhesion and accumulation on endothelial cells are common in both OSA and atherosclerosis. Clinicians should be aware that OSA may be a risk factor for the development of cardiovascular disease. |
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Authors:
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E Kasasbeh; David S Chi; G Krishnaswamy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Southern medical journal Volume: 99 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-09 Completed Date: 2006-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 58-67; quiz 68-9, 81 Citation Subset: AIM; IM |
Affiliation:
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Division of Allergy and Immunology, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiovascular Diseases / blood, etiology* Cytokines / blood* Humans Inflammation / blood Oxidative Stress Risk Factors Sleep Apnea Syndromes / blood, complications* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines |
| Comments/Corrections | |
Erratum In:
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South Med J. 2006 Feb;99(2):163 |
Summary for patients in:
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South Med J. 2006 Jan;99(1):104
[PMID:
16466139
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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