Document Detail


Inflammatory arthritis following ustekinumab treatment for psoriasis: a report of two cases.
MedLine Citation:
PMID:  23278559     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Psoriasis is a chronic inflammatory skin condition, characterized by T-helper (Th) 1 and Th17 cell activation. Ustekinumab is a fully human immunoglobulin G1κ monoclonal antibody that targets the common p40 subunit that is shared by both interleukin (IL)-12 and IL-23, consequently inhibiting T-cell differentiation along both Th1 and Th17 pathways. This is a report of two patients who developed psoriatic arthritis during ustekinumab treatment for psoriasis. Neither patient had a personal or family history of arthritis.
Authors:
A de Souza; T Ali-Shaw; S M Reddy; D Fiorentino; B E Strober
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  168     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  210-2     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
Affiliation:
Department of Dermatology, New York University Hospital for Joint Disease, New York University School of Medicine, New York, NY, U.S.A. Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, U.S.A. Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT, U.S.A.
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