| Inflammatory and anti-inflammatory responsiveness of surfactant proteins in fetal and neonatal rabbit lung. | |
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MedLine Citation:
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PMID: 14605255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous preterm birth due to intrauterine infection is associated with increased concentrations of cytokines in amniotic fluid and in the airways at birth. Intra-amniotic IL-1 induces fetal lung maturity, consistent with the decrease in the incidence of respiratory distress syndrome (RDS) in intrauterine inflammation. On the other hand, antenatal corticosteroid decreases the incidence of RDS in infants born prematurely. The aim of the present study was to investigate the interaction between IL-1 and glucocorticoid in the expression of the surfactant proteins SP-A, -B, and -C. Lung explants from rabbit fetuses at 22 (immature), 27 (transitional), and 30 (mature) d of gestation (term, 30-31 d) and on d 1 after term birth were cultured with dexamethasone (Dx), IL-1alpha, or vehicle in the presence or absence of actinomycin D. According to the present results, IL-1alpha and Dx additively increased the expression of SP-A and SP-B on d 22. Later in gestation, SP-B and SP-C were suppressed by IL-1, whereas glucocorticoid tended to increase the expression of SP-B and SP-C and prevented the IL-1-induced suppression of SP. IL-1alpha and steroid interactively increased the stability of SP mRNA compared with the single agonist, possibly explaining the additive effects on the SP mRNA levels. The present results reveal beneficial additive effects of glucocorticoid and cytokine on lung surfactant. They may explain some of the acute beneficial effects of glucocorticoid therapy in chorioamnionitis before premature birth and in inflammatory lung disease after birth. |
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Authors:
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Outi Vayrynen; Virpi Glumoff; Mikko Hallman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-11-06 |
Journal Detail:
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Title: Pediatric research Volume: 55 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-22 Completed Date: 2004-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Biocenter Oulu, University of Oulu, Kajaanintie 52, 90220 Oulu, Finland. mikko.hallman@oulu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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pharmacology Animals Animals, Newborn Dexamethasone / pharmacology Female Gene Expression / drug effects Humans Infant, Newborn Interleukin-1 / pharmacology Lung / embryology, immunology* Organ Culture Techniques Pneumonia / drug therapy, immunology* Pregnancy Pulmonary Surfactant-Associated Protein A / genetics* Pulmonary Surfactant-Associated Protein B / genetics Pulmonary Surfactant-Associated Protein C / genetics RNA, Messenger / analysis Rabbits Respiratory Distress Syndrome, Newborn / drug therapy, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Interleukin-1; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Protein B; 0/Pulmonary Surfactant-Associated Protein C; 0/RNA, Messenger; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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