Document Detail

Inflammatory and anti-inflammatory responsiveness of surfactant proteins in fetal and neonatal rabbit lung.
MedLine Citation:
PMID:  14605255     Owner:  NLM     Status:  MEDLINE    
Spontaneous preterm birth due to intrauterine infection is associated with increased concentrations of cytokines in amniotic fluid and in the airways at birth. Intra-amniotic IL-1 induces fetal lung maturity, consistent with the decrease in the incidence of respiratory distress syndrome (RDS) in intrauterine inflammation. On the other hand, antenatal corticosteroid decreases the incidence of RDS in infants born prematurely. The aim of the present study was to investigate the interaction between IL-1 and glucocorticoid in the expression of the surfactant proteins SP-A, -B, and -C. Lung explants from rabbit fetuses at 22 (immature), 27 (transitional), and 30 (mature) d of gestation (term, 30-31 d) and on d 1 after term birth were cultured with dexamethasone (Dx), IL-1alpha, or vehicle in the presence or absence of actinomycin D. According to the present results, IL-1alpha and Dx additively increased the expression of SP-A and SP-B on d 22. Later in gestation, SP-B and SP-C were suppressed by IL-1, whereas glucocorticoid tended to increase the expression of SP-B and SP-C and prevented the IL-1-induced suppression of SP. IL-1alpha and steroid interactively increased the stability of SP mRNA compared with the single agonist, possibly explaining the additive effects on the SP mRNA levels. The present results reveal beneficial additive effects of glucocorticoid and cytokine on lung surfactant. They may explain some of the acute beneficial effects of glucocorticoid therapy in chorioamnionitis before premature birth and in inflammatory lung disease after birth.
Outi Vayrynen; Virpi Glumoff; Mikko Hallman
Related Documents :
9468465 - Antenatal thyrotropin-releasing hormone to prevent lung disease in preterm infants. nor...
8058425 - Nasal response to inhaled histamine measured by acoustic rhinometry in infants.
15173495 - Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloprotein...
6747225 - Growth of the fetal lung.
19319975 - Selection and the effect of prenatal smoking.
20887535 - Onset of vocal interaction between parents and newborns in skin-to-skin contact immedia...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-11-06
Journal Detail:
Title:  Pediatric research     Volume:  55     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Department of Pediatrics and Biocenter Oulu, University of Oulu, Kajaanintie 52, 90220 Oulu, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Cortex Hormones / pharmacology
Animals, Newborn
Dexamethasone / pharmacology
Gene Expression / drug effects
Infant, Newborn
Interleukin-1 / pharmacology
Lung / embryology,  immunology*
Organ Culture Techniques
Pneumonia / drug therapy,  immunology*
Pulmonary Surfactant-Associated Protein A / genetics*
Pulmonary Surfactant-Associated Protein B / genetics
Pulmonary Surfactant-Associated Protein C / genetics
RNA, Messenger / analysis
Respiratory Distress Syndrome, Newborn / drug therapy,  immunology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Interleukin-1; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Protein B; 0/Pulmonary Surfactant-Associated Protein C; 0/RNA, Messenger; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal...
Next Document:  Igf-I accelerates ileal epithelial cell migration in culture and newborn mice and may be a mediator ...