Document Detail

Inflammatory role of Toll-like receptors in human and murine adipose tissue.
MedLine Citation:
PMID:  20339530     Owner:  NLM     Status:  MEDLINE    
It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject. We demonstrated a correlation of TLRs expression within and between each depot suggesting a coregulation. Murine 3T3-L1 preadipocyte cells stimulated with Pam3CSK4 induced the expression of some proinflammatory markers. Therefore, beside TLR4, other toll-like receptors are differentially expressed in human fat tissue, and functional in an adipocyte cell line, suggesting that they might participate omental adipose tissue-related inflammation that occurs in obesity.
Odile Poulain-Godefroy; Olivier Le Bacquer; Pauline Plancq; Cécile Lecoeur; François Pattou; Gema Frühbeck; Philippe Froguel
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-22
Journal Detail:
Title:  Mediators of inflammation     Volume:  2010     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823486     Citation Subset:  IM    
CNRS 8199-Institute of Biology, Pasteur Institute, Lille, France.
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MeSH Terms
3T3-L1 Cells
Adipocytes / cytology,  drug effects,  metabolism
Adipose Tissue / metabolism*
Case-Control Studies
Cell Differentiation
Gene Expression
Inflammation / etiology*,  genetics,  metabolism*
Inflammation Mediators / metabolism*
Lipopeptides / pharmacology
Middle Aged
Obesity / etiology,  genetics,  metabolism
RNA, Messenger / genetics,  metabolism
Toll-Like Receptor 1 / genetics,  metabolism
Toll-Like Receptor 2 / agonists,  genetics,  metabolism
Toll-Like Receptor 4 / genetics,  metabolism
Toll-Like Receptor 6 / genetics,  metabolism
Toll-Like Receptors / genetics,  metabolism*
Reg. No./Substance:
0/Inflammation Mediators; 0/Lipopeptides; 0/Pam(3)CSK(4) peptide; 0/RNA, Messenger; 0/TLR2 protein, human; 0/TLR4 protein, human; 0/TLR6 protein, human; 0/Tlr2 protein, mouse; 0/Toll-Like Receptor 1; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4; 0/Toll-Like Receptor 6; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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