| Inflammatory Biomarkers in Patients with Asymptomatic Primary Hyperparathyroidism. | |
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MedLine Citation:
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PMID: 22179481 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT). Materials and Methods: A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects. Results: Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 ± 0.54 vs. 2.24 ± 0.11 mg/l; IL-6: 4.50 ± 0.80 vs. 2.56± 0.29 pg/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively). Conclusion: Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients. |
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Authors:
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Ahmed Alsayed Emam; Sabela Gomaa Mousa; Karema Yousif Ahmed; Adel A Al-Azab |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-16 |
Journal Detail:
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Title: Medical principles and practice : international journal of the Kuwait University, Health Science Centre Volume: - ISSN: 1423-0151 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8901334 Medline TA: Med Princ Pract Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, National Research Center, Cairo, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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