Document Detail


Inflammation versus neurodegeneration: consequences for treatment.
MedLine Citation:
PMID:  17418237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. Additionally axonal damage itself can lead to inflammation and laboratory and clinical observations suggest that inflammation may be neuroprotective. Finally, clinical trials reveal that immunosuppression does not have the predicted effect on axonal damage and disability. Clearly if inflammation is not the primary event but a secondary phenomenon this has important implications in developing treatment regimes.
Authors:
J Palace
Related Documents :
1262897 - Eales' disease with neurological involvement. part 2. pathology and pathogenesis.
16866657 - Scleroderma: it has been a long hard journey.
355697 - A cellular approach to neurological disease.
22823977 - Myeloid malignancies: mutations, models and management.
24261027 - The use of fecal calprotectin and lactoferrin in patients with ibd. review.
16837207 - Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral scler...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-04-05
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  259     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
Affiliation:
Department of Clinical Neurology, Woodstock Rd., Oxford OX2 6HE, UK. jacqueline.palace@clinical-neurology.oxford.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Humans
Inflammation / therapy*
Neurodegenerative Diseases / therapy*
Treatment Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-prod...
Next Document:  A probabilistic model of reserve design.