| Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development. | |
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MedLine Citation:
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PMID: 20373866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection-associated chronic inflammation plays an important role in tumorigenesis, and macrophages are a key player in both inflammation and tumorigenesis. Tumor-associated macrophages accelerate tumorigenesis through the enhancement of angiogenesis, remodeling and the suppression of antitumor immunity. Helicobacter pylori infection induces inflammatory responses, which are closely associated with gastric cancer development. Recent studies using mouse models indicate that activated macrophages in the infected and inflamed gastric mucosa express TNF-alpha, which stimulates the surrounding epithelial cells to promote Wnt signaling activity. Such a promotion of Wnt signaling activity beyond the threshold for tumorigenesis may, therefore contribute to gastric cancer development. Accordingly, it is possible that the TNF-alpha-induced promotion of Wnt signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis. |
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Authors:
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Keisuke Oguma; Hiroko Oshima; Masanobu Oshima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Future oncology (London, England) Volume: 6 ISSN: 1744-8301 ISO Abbreviation: Future Oncol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256629 Medline TA: Future Oncol Country: England |
Other Details:
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Languages: eng Pagination: 515-26 Citation Subset: IM |
Affiliation:
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Division of Genetics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192 Japan. koguma@kenroku.kanazawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Helicobacter Infections / immunology Humans Inflammation Mice Stomach Neoplasms / immunology, physiopathology* Tumor Necrosis Factors / metabolism* Wnt1 Protein / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factors; 0/Wnt1 Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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