Document Detail

Inflammation and proinflammatory cytokine production, but no demyelination of facial nerves, in experimental autoimmune neuritis in Lewis rats.
MedLine Citation:
PMID:  12864976     Owner:  NLM     Status:  MEDLINE    
Experimental autoimmune neuritis (EAN) is a CD4(+) T cell-mediated, inflammatory demyelinating disease of the peripheral nervous system (PNS) that serves as a model for Guillain-Barré syndrome (GBS) in humans. The facial nerve paralysis is relatively commonly found in GBS patients. Here, EAN was established in Lewis rats by immunization with P2 peptide 57-81, a purified component of peripheral nerve myelin, and Freund's complete adjuvant (FCA). To study whether the facial nerves are involved in the pathogenic process during the EAN course, we observed the clinical and pathological changes as well as cytokine production in facial nerves on Day 14 postimmunization (p.i.), i.e. at height of clinical EAN. As a result, all rats immunized with P2 peptide 57-81 developed severe EAN on Day 14 p.i., but none of the rats manifested clinical signs of facial nerve paralysis. Additionally, only mild inflammatory cell infiltration and proinflammatory cytokine, interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha) production as well as devoid demyelination were seen in facial nerves of the EAN rats. On the contrary, severe inflammation and demyelination as well as upregulated IFN-gamma and TNF-alpha production were observed in sciatic nerves of the same EAN rats. The underlying mechanism for the difference of the local manifestation of the disease process of EAN remains to be resolved.
Wei Zhu; Eilhard Mix; Jie Zhu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  140     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2003-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Department of Otorhinolaryngology, The First Hospital, JiLin University, Changchun, China.
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MeSH Terms
Cell Movement / immunology
Cytokines / biosynthesis*
Demyelinating Diseases / immunology*,  pathology*,  physiopathology
Facial Nerve / immunology*,  metabolism,  pathology*
Inflammation Mediators / metabolism*
Myelin P2 Protein / administration & dosage
Myelin Sheath / physiology
Neuritis, Autoimmune, Experimental / immunology*,  pathology*,  physiopathology
Rats, Inbred Lew
Sciatic Nerve / immunology,  metabolism,  pathology,  physiopathology
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Myelin P2 Protein

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