| Inflammation and pregnancy: the role of the immune system at the implantation site. | |
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MedLine Citation:
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PMID: 21401634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concept that pregnancy is associated with immune suppression has created a myth of pregnancy as a state of immunological weakness and, therefore, of increased susceptibility to infectious diseases. A challenging question is whether the maternal immune system is a friend or a foe of pregnancy. In this review, we discuss data associated to the role of the immune system during pregnancy. We propose a new paradigm in terms of the fetal-maternal immune interaction as well as the immunological response of the mother to microorganism. Our challenge is to better understand the immunology of pregnancy in order to deliver the appropriate treatment to patients with pregnancy complications as well as to determine public policies for the protection of pregnant women during pandemics. |
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Authors:
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Gil Mor; Ingrid Cardenas; Vikki Abrahams; Seth Guller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1221 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-15 Completed Date: 2011-05-06 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 80-7 Citation Subset: IM |
Copyright Information:
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© 2011 New York Academy of Sciences. |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, Connecticut, USA. gil.mor@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dendritic Cells
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immunology Embryo Implantation / immunology Female Humans Immune System / immunology* Inflammation / immunology* Pregnancy Th1 Cells / immunology Th2 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD054713/HD/NICHD NIH HHS; P01 HD054713-01A2/HD/NICHD NIH HHS; P01 HD054713-02/HD/NICHD NIH HHS; P01 HD054713-03/HD/NICHD NIH HHS; P01HD054713/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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