Document Detail

Inflammation and pregnancy: the role of the immune system at the implantation site.
MedLine Citation:
PMID:  21401634     Owner:  NLM     Status:  MEDLINE    
The concept that pregnancy is associated with immune suppression has created a myth of pregnancy as a state of immunological weakness and, therefore, of increased susceptibility to infectious diseases. A challenging question is whether the maternal immune system is a friend or a foe of pregnancy. In this review, we discuss data associated to the role of the immune system during pregnancy. We propose a new paradigm in terms of the fetal-maternal immune interaction as well as the immunological response of the mother to microorganism. Our challenge is to better understand the immunology of pregnancy in order to deliver the appropriate treatment to patients with pregnancy complications as well as to determine public policies for the protection of pregnant women during pandemics.
Gil Mor; Ingrid Cardenas; Vikki Abrahams; Seth Guller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1221     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-05-06     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-7     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
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MeSH Terms
Dendritic Cells / immunology
Embryo Implantation / immunology
Immune System / immunology*
Inflammation / immunology*
Th1 Cells / immunology
Th2 Cells / immunology
Grant Support
P01 HD054713/HD/NICHD NIH HHS; P01 HD054713-01A2/HD/NICHD NIH HHS; P01 HD054713-02/HD/NICHD NIH HHS; P01 HD054713-03/HD/NICHD NIH HHS; P01HD054713/HD/NICHD NIH HHS

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