Document Detail

Inflammation and overweight in peritoneal dialysis: is there an association?
MedLine Citation:
PMID:  19839849     Owner:  NLM     Status:  MEDLINE    
More than 30% of the patients on peritoneal dialysis show chronic systemic inflammatory activity with high levels of C-reactive protein. The purpose of this cross-sectional study was to investigate the influence of the inflammatory state on clinical and nutritional markers in patients on peritoneal dialysis. Twenty-seven patients were included: mean age was 57.6 +/- 19 years, 48% were male, and median time on peritoneal dialysis was 16.0 (8.3; 35.8) months. Clinical, dialytic, laboratory, anthropometric and electric bioimpedance data were collected with the sample stratified for C-reactive protein. In patients, the levels of Interleukin-6 and tumor necrosis factor-alpha were higher, while adiponectin levels were lower than in healthy individuals (p < or = 0.001), indicating the presence of inflammatory activity in the sample. When compared to patients with C-reactive protein <1 mg/dL, those with > or =1mg/dL showed higher body mass index (29.4 +/- 6.1 vs. 24.4 +/- 4.5 kg/m(2); p = 0.009), percent of standard body weight (124.5 +/- 25.4 vs. 106.8 +/- 17.9 %; p = 0.012), and percent of body fat as assessed by both anthropometry (31.3 +/- 9.9 vs. 23.9 +/- 9.1%; p = 0.056) and bioimpedance (38.9 +/- 6.3 vs. 26.2 +/- 12.6 %; p < 0.001). Patients with C-reactive protein > or =1mg/dL also exhibited higher levels of ferritin (701 +/- 568 vs. 532 +/- 356 ng/mL; p =0.054) and lower total lymphocyte count (median 1838 vs. 1638 mm3; p = 0.001). In conclusion, higher body mass index and body fat markers were associated with C-reactive protein > or = 1mg/dL, and higher C-reactive protein was associated with immunocompetence impairment evidenced by the lower total lymphocyte count. Our findings confirm the relationship between inflammation, body fat, and immunocompetence, which may be superimposed potentializing the inflammatory status.
Aline de Araujo Antunes; Francieli Delatim Vannini; Luis Cuadrado Martin; Andre Luis Balbi; Daniela Ponce; H??lio Rubens Nunes; Pasqual Barretti; Jacqueline Costa Teixeira Caramori
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal failure     Volume:  31     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Department of Clinical Medicine, Botucatu School of Medicine, S??o Paulo University, UNESP, Botucatu, S??o Paulo State, Brazil.
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MeSH Terms
Blood Chemical Analysis
Body Composition
Body Mass Index
C-Reactive Protein / metabolism*
Cross-Sectional Studies
Cytokines / blood
Follow-Up Studies
Inflammation / epidemiology*,  etiology
Inflammation Mediators / blood
Kidney Failure, Chronic / diagnosis,  therapy*
Kidney Function Tests
Middle Aged
Nutrition Assessment
Overweight / epidemiology*,  etiology
Peritoneal Dialysis / adverse effects,  methods*
Reference Values
Risk Assessment
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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