Document Detail

Inflammation and neural signaling: etiologic mechanisms of the cancer treatment-related symptom cluster.
MedLine Citation:
PMID:  23314015     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Cancer patients undergoing treatment with cytotoxic chemotherapeutic agents (CCAs) often experience a cluster of treatment-related symptoms, which include fatigue, loss of appetite, disturbed sleep, depressed mood, cognitive difficulties, and changes in body composition. This symptom cluster collectively referred to herein as cancer treatment-related symptoms (CTRSs) decrease quality of life, and physical and social functioning. The preclinical and clinical studies described in this review represent important progress in understanding potential underlying mechanisms of CTRS.
RECENT FINDINGS: Recent studies support a role for CCA-induced interleukin-1β (IL-1β) signaling in the cause of CTRS. CCAs may share a common ability to activate intracellular stress response pathways to trigger the synthesis, processing, and release of IL-1β from immune cells. Fatigue, sleep disturbance, and cognitive difficulties in cancer patients exposed to CCAs correlate with plasma levels of IL-6, IL-1 receptor antagonist, and soluble tumor necrosis factor receptor-I/II, surrogate markers of IL-1β-mediated central nervous system (CNS) inflammation. Additional preclinical work suggests IL-1β-mediated CNS inflammation may cause CTRS by altering hypothalamic and hippocampal functioning.
SUMMARY: Although additional research is necessary to further establish the link between CCA exposure, IL-1β-mediated inflammatory processes and CTRS, these data provide hints for future studies and therapeutic approaches in ameliorating these symptoms in cancer patients.
Lisa J Wood; Kristianna Weymann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in supportive and palliative care     Volume:  7     ISSN:  1751-4266     ISO Abbreviation:  Curr Opin Support Palliat Care     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-02     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101297402     Medline TA:  Curr Opin Support Palliat Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / adverse effects*,  therapeutic use
Cognition Disorders / chemically induced,  complications
Fatigue / chemically induced,  complications
Hypothalamus / drug effects,  physiology
Illness Behavior / drug effects*
Inflammation / blood,  chemically induced*,  complications
Interleukin-1beta / blood,  drug effects*,  physiology
Interleukin-6 / blood,  physiology
Mood Disorders / chemically induced
Neoplasms / complications,  drug therapy*
Quality of Life*
Receptors, Interleukin / blood,  drug effects,  physiology
Receptors, Tumor Necrosis Factor / blood,  drug effects,  physiology
Sickness Impact Profile
Signal Transduction / drug effects*
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Interleukin-1beta; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Tumor Necrosis Factor

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